J
James F. Beck
Researcher at University of Jena
Publications - 134
Citations - 4548
James F. Beck is an academic researcher from University of Jena. The author has contributed to research in topics: Transplantation & Apoptosis. The author has an hindex of 35, co-authored 129 publications receiving 4208 citations. Previous affiliations of James F. Beck include Boston Children's Hospital.
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Journal ArticleDOI
The Leukotriene LTD4 Receptor Antagonist Mk571 Specifically Modulates MRP Associated Multidrug Resistance
TL;DR: The results point to a relationship between MRP and a conjugate transporter and identify MK571 as a new tool structure for developing modulators specific for a MRP associated multidrug resistance.
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Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian study.
K. Winkler,G Beron,Rainer Kotz,Mechthild Salzer-Kuntschik,James F. Beck,W. Beck,W. Brandeis,Ebell W,Erttmann R,Ulrich Göbel +9 more
TL;DR: The over-all increase in CDF rate does not reach statistical significance, it does, however, for the younger (less than or equal to 12 years) and for male patients, which is assumed to be the effect of increasing the methotrexate dose from 6 to 12 g/m2 in the COSS -80 study.
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Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?
Peter Bader,Hermann Kreyenberg,W Hoelle,Gregor Dueckers,Rupert Handgretinger,Peter Lang,Bernhard Kremens,Dagmar Dilloo,Karl-Walter Sykora,Martin Schrappe,Charlotte M. Niemeyer,Arend von Stackelberg,Bernd Gruhn,Günter Henze,Johann Greil,Dietrich Niethammer,Klaus Dietz,James F. Beck,Thomas Klingebiel +18 more
TL;DR: Serial analysis of chimerism reliably identifies patients at highest risk to relapse, and the 3-year EFS of patients with increasing MC without immunotherapy was 0, by which overt relapse could be prevented in a considerable group of patients.
Journal ArticleDOI
Concordant genotype of upper and lower airways P aeruginosa and S aureus isolates in cystic fibrosis
Jochen G. Mainz,Lutz Naehrlich,M. Schien,Manfred Käding,Isabella Schiller,Susanne Mayr,Gerlind Schneider,Bärbel Wiedemann,Lutz Wiehlmann,Nina Cramer,Wolfgang Pfister,Barbara C. Kahl,James F. Beck,Burkhard Tümmler +13 more
TL;DR: The presence of identical genotypes in UAW and LAW suggests that the UAW play a role as a reservoir of S aureus and P aeruginosa in CF, and further longitudinal analyses and comparison with invasive methods are required.
Journal ArticleDOI
Minimal residual disease (MRD) status prior to allogeneic stem cell transplantation is a powerful predictor for post-transplant outcome in children with ALL
Peter Bader,J Hancock,Hermann Kreyenberg,N. J. Goulden,Dietrich Niethammer,Anthony Oakhill,Colin G. Steward,Rupert Handgretinger,James F. Beck,T. Klingebiel +9 more
TL;DR: It is observed that a minority of children with high-level pre-BMT MRD can enter long lasting remission, and the possible role for acute GVHD coupled with a graft-versus-leukaemia effect in the clearance of high level MRD in patients with ALL is discussed.