R
Rupert Handgretinger
Researcher at Boston Children's Hospital
Publications - 582
Citations - 27611
Rupert Handgretinger is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 79, co-authored 549 publications receiving 24356 citations. Previous affiliations of Rupert Handgretinger include Necker-Enfants Malades Hospital & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Leonard D. Shultz,Bonnie L. Lyons,Lisa M. Burzenski,Bruce Gott,Xiaohua Chen,Stanley Chaleff,Malak Kotb,Stephen D. Gillies,Marie King,Julie A. Mangada,Dale L. Greiner,Rupert Handgretinger +11 more
TL;DR: NOD-scid IL2Rγnull mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment.
Journal ArticleDOI
Truncating Mutations of hSNF5/INI1 in Aggressive Paediatric Cancer
Isabella Versteege,Nicolas Sevenet,Julian Lange,Marie-Françoise Rousseau-Merck,Peter F. Ambros,Rupert Handgretinger,Alain Aurias,Olivier Delattre +7 more
TL;DR: The observation of bi-allelic alterations of hSNF5/INI1 in MRTs suggests that loss-of-function mutations of h snf5/inI1 contribute to oncogenesis, and the most frequently deleted part of chromosome 22q11.2 is mapped.
Journal ArticleDOI
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
Ching-Hon Pui,Dario Campana,Deqing Pei,W. Paul Bowman,John T. Sandlund,Sue C. Kaste,Raul C. Ribeiro,Jeffrey E. Rubnitz,Susana C. Raimondi,Mihaela Onciu,Elaine Coustan-Smith,Larry E. Kun,Sima Jeha,Cheng Cheng,Scott C. Howard,Vickey Simmons,Amy Bayles,Monika L. Metzger,James M. Boyett,Wing Leung,Rupert Handgretinger,James R. Downing,William E. Evans,Mary V. Relling +23 more
TL;DR: With effective risk-adjusted chemotherapy, prophylactic cranial irradiation can be safely omitted from the treatment of childhood ALL.
Journal ArticleDOI
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
Michael S. D. Kormann,Günther Hasenpusch,Manish K. Aneja,Gabriela Nica,Andreas W. Flemmer,Susanne Herber-Jonat,Marceline Huppmann,Lauren Mays,Marta C Illenyi,Andrea Schams,Matthias Griese,Iris Bittmann,Rupert Handgretinger,Dominik Hartl,Joseph Rosenecker,Carsten Rudolph +15 more
TL;DR: In a mouse model of a lethal congenital lung disease caused by a lack of surfactant protein B (SP-B), twice weekly local application of an aerosol of modified SP-B mRNA to the lung restored 71% of the wild-type SP- B expression, and treated mice survived until the predetermined end of the study after 28 days.
Journal ArticleDOI
T-helper-1-cell cytokines drive cancer into senescence
Heidi Braumüller,Thomas Wieder,Ellen Brenner,Sonja Aßmann,Matthias Hahn,Mohammed Alkhaled,Karin Schilbach,Frank Essmann,Manfred Kneilling,Christoph M. Griessinger,Felicia Ranta,Susanne Ullrich,Ralph Mocikat,Kilian Braungart,Tarun Mehra,Birgit Fehrenbacher,Julia Berdel,Heike Niessner,Friedegund Meier,Maries van den Broek,Hans-Ulrich Häring,Rupert Handgretinger,Leticia Quintanilla-Martinez,Falko Fend,Marina Pesic,Jürgen Bauer,Lars Zender,Martin Schaller,Klaus Schulze-Osthoff,Martin Röcken +29 more
TL;DR: The combined action of the T-helper-1-cell cytokines IFN-γ and tumour necrosis factor (TNF) directly induces permanent growth arrest in cancers, a general mechanism for arresting cancer progression.