K
Karl-Walter Sykora
Researcher at Hannover Medical School
Publications - 107
Citations - 5689
Karl-Walter Sykora is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 30, co-authored 105 publications receiving 5118 citations. Previous affiliations of Karl-Walter Sykora include Boston Children's Hospital & Hochschule Hannover.
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Journal ArticleDOI
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Erik-Oliver Glocker,Daniel Kotlarz,Kaan Boztug,E. Michael Gertz,Alejandro A. Schäffer,Fatih Noyan,Mario Perro,Jana Diestelhorst,Anna Allroth,Dhaarini Murugan,Nadine Hätscher,Dietmar Pfeifer,Karl-Walter Sykora,Martin Sauer,Hans Kreipe,Martin Lacher,Rainer Nustede,Cristina Woellner,Ulrich Baumann,Ulrich Salzer,Sibylle Koletzko,Neil Shah,Anthony W. Segal,Axel Sauerbrey,Stephan Buderus,Scott B. Snapper,Bodo Grimbacher,Christoph Klein +27 more
TL;DR: Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine, and resulted in disease remission in one patient.
Journal ArticleDOI
CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells.
Roland Jacobs,Gabriele Hintzen,Almut Kemper,Katrin Beul,Sandra Kempf,Georg M. N. Behrens,Karl-Walter Sykora,Reinhold E. Schmidt +7 more
TL;DR: The data support the view that CD56bright cells are specialized NK cells that regulate immunological response mechanisms rather by cytokine supply than by their cytotoxic potential.
Journal ArticleDOI
Prognostic Value of Minimal Residual Disease Quantification Before Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia: The ALL-REZ BFM Study Group
Peter Bader,Hermann Kreyenberg,Günter Henze,Cornelia Eckert,Miriam Reising,Andre Willasch,Andrea Barth,Arndt Borkhardt,Christina Peters,Rupert Handgretinger,Karl-Walter Sykora,Wolfgang Holter,Hartmut Kabisch,Thomas Klingebiel,Arend von Stackelberg +14 more
TL;DR: Minimal residual disease (MRD) before allogeneic stem-cell transplantation was shown to predict outcome in children with relapsed acute lymphoblastic leukemia in retrospective analysis and is an important predictor for post-transplantation outcome.
Journal ArticleDOI
Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Münster Group.
Alfred Reiter,Martin Schrappe,Reza Parwaresch,Günter Henze,St. Müller-Weihrich,S Sauter,Karl-Walter Sykora,Wolf-Dieter Ludwig,Helmut Gadner,Hansjörg Riehm +9 more
TL;DR: This therapy strategy provided patients of all NHL subtypes with an equally high chance to survive event-free, except patients with PTCL, in which three of four patients suffered from relapse.
Journal ArticleDOI
Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?
Peter Bader,Hermann Kreyenberg,W Hoelle,Gregor Dueckers,Rupert Handgretinger,Peter Lang,Bernhard Kremens,Dagmar Dilloo,Karl-Walter Sykora,Martin Schrappe,Charlotte M. Niemeyer,Arend von Stackelberg,Bernd Gruhn,Günter Henze,Johann Greil,Dietrich Niethammer,Klaus Dietz,James F. Beck,Thomas Klingebiel +18 more
TL;DR: Serial analysis of chimerism reliably identifies patients at highest risk to relapse, and the 3-year EFS of patients with increasing MC without immunotherapy was 0, by which overt relapse could be prevented in a considerable group of patients.