J
James H. Gerlach
Researcher at Queen's University
Publications - 20
Citations - 4939
James H. Gerlach is an academic researcher from Queen's University. The author has contributed to research in topics: Multiple drug resistance & Gene expression. The author has an hindex of 14, co-authored 20 publications receiving 4845 citations. Previous affiliations of James H. Gerlach include University of Arizona.
Papers
More filters
Journal ArticleDOI
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
Susan P.C. Cole,Gabu Bhardwaj,James H. Gerlach,J. E. Mackie,Caroline E. Grant,Kurt C. Almquist,Alistair J. Stewart,Ebba U. Kurz,A. M. V. Duncan,Roger G. Deeley +9 more
TL;DR: Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression, and the mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily.
Journal Article
Multidrug Resistance in a Human Small Cell Lung Cancer Cell Line Selected in Adriamycin
TL;DR: A multidrug resistant variant (H69AR) of the human small cell lung cancer cell line NCI-H69 was obtained by culturing these cells in gradually increasing doses of Adriamycin up to 0.8 microM after a total of 14 months.
Journal Article
Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.
TL;DR: The drug sensitivity/resistance pattern of the resistant cell line correlates well with clinical observations indicating the potential of this cell line as a model for resistance in multiple myeloma.
Journal Article
Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels.
TL;DR: It is found that MRP3 and MRP1, but not MRP2, protein levels correlated with decreased sensitivity of these lung cancer cell lines to doxorubicin, VCR, VP-16, and cis-diamminedicholoroplatinum(II).
Journal ArticleDOI
Membrane Topology of the Multidrug Resistance Protein (MRP) A STUDY OF GLYCOSYLATION-SITE MUTANTS REVEALS AN EXTRACYTOSOLIC NH2 TERMINUS
David R. Hipfner,Kurt C. Almquist,Elaine M. Leslie,James H. Gerlach,Caroline E. Grant,Roger G. Deeley,Susan P.C. Cole +6 more
TL;DR: In this article, the authors identify which of the 14 N-glycosylation sequons in multidrug resistance protein (MRP) are utilized to aid in determining the topology most likely to be correct, which may have important implications for the further understanding of the interaction of drugs with MRP.