J
James Hewinson
Researcher at Wellcome Trust Sanger Institute
Publications - 31
Citations - 1298
James Hewinson is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Germline & Germline mutation. The author has an hindex of 15, co-authored 26 publications receiving 835 citations. Previous affiliations of James Hewinson include University of Bristol & University of Bath.
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Journal ArticleDOI
Essential Role of Phox2b-Expressing Ventrolateral Brainstem Neurons in the Chemosensory Control of Inspiration and Expiration
Nephtali Marina,Ana Paula Abdala,Stefan Trapp,Aihua Li,Eugene E. Nattie,James Hewinson,Jeffrey C. Smith,Julian F. R. Paton,Alexander V. Gourine +8 more
TL;DR: Inspiratory responses evoked by rising levels of CO2 in the breathing air were reduced in anesthetized rats with denervated carotid bodies and conscious rats with peripheral chemoreceptors intact, indicating a crucial dependence of central expiratory drive upon Phox2b-expressing neurons of the ventrolateral brainstem.
Journal ArticleDOI
Optoactivation of Locus Ceruleus Neurons Evokes Bidirectional Changes in Thermal Nociception in Rats
Louise Hickey,Yong Li,Sarah J. Fyson,Thomas C. Watson,Ray Perrins,James Hewinson,Anja G. Teschemacher,Hidemasa Furue,Bridget M. Lumb,Anthony E. Pickering +9 more
TL;DR: The LC is capable of exerting potent, discrete, bidirectional influences on thermal nociception that are produced by specific subpopulations of noradrenergic neurons, which reflects an underlying functional heterogeneity of the influence of the LC on the processing of nocICEptive information.
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A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes.
TL;DR: It is demonstrated that ATP-induced cellular oxidation is critical for caspase-1 activation and subsequent IL-1β processing and signaling via NADPH oxidase activity is fundamental for the processing of mature IL- 1β induced by P2X7R stimulation.
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Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.
Melissa Q. McCreery,Kyle D. Halliwill,Douglas Chin,Reyno Delrosario,Gillian L. Hirst,Peter Vuong,Kuang-Yu Jen,James Hewinson,David J. Adams,Allan Balmain +9 more
TL;DR: Mouse tumors that mimic the genetic heterogeneity of human cancers can aid the understanding of the clonal evolution of metastasis and provide a realistic model for the testing of novel therapies.
Journal ArticleDOI
Life histories of myeloproliferative neoplasms inferred from phylogenies
Nicholas Williams,Joe Lee,Emily G. Mitchell,Luiza Moore,E. Joanna Baxter,James Hewinson,Kevin J. Dawson,Andrew Menzies,Anna L. Godfrey,Anthony R. Green,Peter J. Campbell,Jyoti Nangalia +11 more
TL;DR: In this paper , the authors used whole-genome sequencing of 1,013 clonal haematopoietic colonies from 12 patients with myeloproliferative neoplasms.