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Bridget M. Lumb
Researcher at University of Bristol
Publications - 85
Citations - 3526
Bridget M. Lumb is an academic researcher from University of Bristol. The author has contributed to research in topics: Nociception & Nociceptor. The author has an hindex of 31, co-authored 82 publications receiving 3067 citations. Previous affiliations of Bridget M. Lumb include University of Birmingham & Merck & Co..
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Descending control of nociception: Specificity, recruitment and plasticity.
TL;DR: Analysis of the circuitry within the RVM reveals that the neural basis for bidirectional control from the midline system is two populations of neurons, ON-cells and OFF-cells, that are differentially recruited by higher structures important in fear, illness and psychological stress to enhance or inhibit pain.
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A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states
Sandrine M Géranton,Lydia Jiménez-Díaz,Carole Torsney,Keri K Tochiki,Sarah A Stuart,J L Leith,Bridget M. Lumb,Stephen P. Hunt +7 more
TL;DR: It is shown that persistent pain states, but not acute pain behavior, are substantially alleviated by centrally administered rapamycin, an inhibitor of the mTOR pathway, and this work suggests a new pharmacological route for therapeutic intervention in persistentPain states.
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Local Translation in Primary Afferent Fibers Regulates Nociception
Lydia Jiménez-Díaz,Lydia Jiménez-Díaz,Sandrine M Géranton,Gayle M. Passmore,J. Lianne Leith,Amy S. Fisher,Laura Berliocchi,Anantha K. Sivasubramaniam,A. Sheasby,Bridget M. Lumb,Stephen P. Hunt +10 more
TL;DR: It is found that rapamycin blunted the heightened response to mechanical stimulation that develops around a site of injury and reduced the long-term mechanical hypersensitivity that follows partial peripheral nerve damage - a widely used model of chronic pain.
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Optoactivation of Locus Ceruleus Neurons Evokes Bidirectional Changes in Thermal Nociception in Rats
Louise Hickey,Yong Li,Sarah J. Fyson,Thomas C. Watson,Ray Perrins,James Hewinson,Anja G. Teschemacher,Hidemasa Furue,Bridget M. Lumb,Anthony E. Pickering +9 more
TL;DR: The LC is capable of exerting potent, discrete, bidirectional influences on thermal nociception that are produced by specific subpopulations of noradrenergic neurons, which reflects an underlying functional heterogeneity of the influence of the LC on the processing of nocICEptive information.
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Cerebellar Modules and Their Role as Operational Cerebellar Processing Units
Richard Apps,Richard Hawkes,Sho Aoki,Sho Aoki,Fredrik Bengtsson,Amanda M Brown,Amanda M Brown,Gang Chen,Timothy J. Ebner,Philippe Isope,Henrik Jörntell,Elizabeth P. Lackey,Elizabeth P. Lackey,Charlotte Lawrenson,Bridget M. Lumb,Martijn Schonewille,Roy V. Sillitoe,Roy V. Sillitoe,Ludovic Spaeth,Izumi Sugihara,Antoine M. Valera,Jan Voogd,Douglas R. Wylie,Tom J. H. Ruigrok +23 more
TL;DR: Despite the general consensus that the cerebellum has a modular organization, many questions remain, so it is hoped that this joint review will inspire future cerebellar research to understand how this brain structure makes its vital contribution to behavior in its most general form.