J
James L. Mueller
Researcher at University of California, San Francisco
Publications - 50
Citations - 6093
James L. Mueller is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: B cell & Antigen. The author has an hindex of 30, co-authored 48 publications receiving 5274 citations. Previous affiliations of James L. Mueller include University of California, San Diego & Ludwig Institute for Cancer Research.
Papers
More filters
Journal ArticleDOI
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome
Hal M. Hoffman,James L. Mueller,David H. Broide,Alan A. Wanderer,Richard D. Kolodner,Richard D. Kolodner +5 more
TL;DR: A gene, called CIAS1, is expressed in peripheral blood leukocytes and encodes a protein with a pyrin domain, a nucleotide-binding site (NBS, NACHT subfamily) domain and a leucine-rich repeat (LRR) motif region, suggesting a role in the regulation of inflammation and apoptosis.
Journal ArticleDOI
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Mohamed Lamkanfi,James L. Mueller,Alberto C. Vitari,Shahram Misaghi,Anna V. Fedorova,Kurt Deshayes,Wyne P. Lee,Hal M. Hoffman,Vishva M. Dixit +8 more
TL;DR: Glyburide, a sulfonylurea drug commonly used to treat type 2 diabetes, shuts down IL-1β secretion by preventing Cyropyrin activation.
Journal ArticleDOI
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
Hal M. Hoffman,Hal M. Hoffman,Sanna Rosengren,David L. Boyle,Jae Y Cho,Jyothi Nayar,James L. Mueller,Justin P. Anderson,Alan A. Wanderer,Gary S. Firestein +9 more
TL;DR: The ability of IL-1Ra to prevent the clinical features and haematological and biochemical changes in patients with FCAS indicates a central role for interleukin 1beta in this disorder and support a new therapy for a disorder with no previously known acceptable treatment.
Journal ArticleDOI
The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model.
Ivona Aksentijevich,Christopher D. Putnam,Elaine F. Remmers,James L. Mueller,Julie Le,Richard D. Kolodner,Zachary Moak,Michael Chuang,Frances Austin,Raphaela Goldbach-Mansky,Hal M. Hoffman,Daniel L. Kastner +11 more
TL;DR: Investigation of the structural effect of disease-causing mutations on cryopyrin provides insight into potential molecular mechanisms by which cryopyrsin mutations can inappropriately activate an inflammatory response.
Journal ArticleDOI
Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity
Susannah Brydges,Susannah Brydges,James L. Mueller,James L. Mueller,Matthew D. McGeough,Carla A. Peña,Amirhossein Misaghi,Chhavi Gandhi,Christopher D. Putnam,Christopher D. Putnam,David L. Boyle,Gary S. Firestein,Anthony A. Horner,Pejman Soroosh,Wendy T. Watford,John J. O'Shea,Daniel L. Kastner,Hal M. Hoffman +17 more
TL;DR: It is suggested that CAPS are true inflammasome-mediated diseases and provide insight for more common inflammatory disorders.