J
Julie Le
Researcher at National Institutes of Health
Publications - 3
Citations - 521
Julie Le is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Single-nucleotide polymorphism & Muckle–Wells syndrome. The author has an hindex of 3, co-authored 3 publications receiving 438 citations.
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The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model.
Ivona Aksentijevich,Christopher D. Putnam,Elaine F. Remmers,James L. Mueller,Julie Le,Richard D. Kolodner,Zachary Moak,Michael Chuang,Frances Austin,Raphaela Goldbach-Mansky,Hal M. Hoffman,Daniel L. Kastner +11 more
TL;DR: Investigation of the structural effect of disease-causing mutations on cryopyrin provides insight into potential molecular mechanisms by which cryopyrsin mutations can inappropriately activate an inflammatory response.
Journal ArticleDOI
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility.
Masaki Takeuchi,Masaki Takeuchi,Nobuhisa Mizuki,Akira Meguro,Michael J. Ombrello,Yohei Kirino,Colleen Satorius,Julie Le,Mary Blake,Burak Erer,Tatsukata Kawagoe,Duran Ustek,Ilknur Tugal-Tutkun,Emire Seyahi,Yilmaz Ozyazgan,Inês Sousa,Inês Sousa,Fereydoun Davatchi,Vânia Francisco,Vânia Francisco,Farhad Shahram,Bahar Sadeghi Abdollahi,Abdolhadi Nadji,Niloofar Mojarad Shafiee,Fahmida Ghaderibarmi,Shigeaki Ohno,Atsuhisa Ueda,Yoshiaki Ishigatsubo,Massimo Gadina,Sofia A. Oliveira,Sofia A. Oliveira,Ahmet Gül,Daniel L. Kastner,Elaine F. Remmers +33 more
TL;DR: The findings extend the list of susceptibility genes shared with Crohn's disease and leprosy and implicate mucosal factors and the innate immune response to microbial exposure in Behçet's disease susceptibility.
Journal ArticleDOI
Common genetic susceptibility loci link PFAPA syndrome, Behçet’s disease, and recurrent aphthous stomatitis
Kalpana Manthiram,Silvia Preite,Fatma Dedeoglu,Selcan Demir,Seza Ozen,Kathryn M. Edwards,Sivia K. Lapidus,Alexander E. Katz,Henry M. Feder,Maranda Lawton,Greg R. Licameli,Peter F. Wright,Julie Le,Karyl S. Barron,Amanda K. Ombrello,Beverly K. Barham,Tina Romeo,Anne Jones,Hemalatha Srinivasalu,Pamela A. Mudd,Roberta L. DeBiasi,Ahmet Gül,Gary S. Marshall,Olcay Y Jones,Settara C. Chandrasekharappa,Yuriy Stepanovskiy,Polly J. Ferguson,Pamela L. Schwartzberg,Elaine F. Remmers,Daniel L. Kastner +29 more
TL;DR: The results illustrate genetic similarities among recurrent aphthous stomatitis, PFAPA, and Behçet’s disease, placing these disorders on a common spectrum, with recurrent aphtous stromatitis on the mild end, Behçets disease on the severe end, andPFAPA intermediate.