J
James R. Bunzow
Researcher at Vollum Institute
Publications - 8
Citations - 1816
James R. Bunzow is an academic researcher from Vollum Institute. The author has contributed to research in topics: Dopamine receptor D2 & Dopamine receptor D1. The author has an hindex of 8, co-authored 8 publications receiving 1788 citations. Previous affiliations of James R. Bunzow include University of Michigan.
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Journal ArticleDOI
Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type
James R. Bunzow,Carmen Sáez,Marty Mortrud,Claudia Bouvier,John T. Williams,Malcolm J. Low,David K. Grandy,David K. Grandy +7 more
TL;DR: In situ hybridization analysis revealed that LC132 mRNA is highly expressed in several rat brain areas, including the cerebral cortex, thalamus, subfornical organ, habenula, hypothalamus, central gray, dorsal raphe, locus coeruleus and the dorsal horn of the spinal cord.
Journal ArticleDOI
Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization- receptor autoradiographic analysis
Alfred Mansour,James H. Meador-Woodruff,James R. Bunzow,Olivier Civelli,Huda Akil,Stanley J. Watson +5 more
TL;DR: Analysis of adjacent tissue sections in which receptor autoradiography and in situ hybridization had been performed revealed several brain regions where the D2 binding site and corresponding mRNA appear to be similarly distributed, including the caudate-putamen, nucleus accumbens, olfactory tubercle, globus pallidus, substantia nigra, and ventral tegmental area.
Journal ArticleDOI
Distribution of D2 dopamine receptor mRNA in rat brain.
James H. Meador-Woodruff,Alfred Mansour,James R. Bunzow,H. H. M. Van Tol,Stanley J. Watson,Olivier Civelli +5 more
TL;DR: D2 mRNA was found both in dopamine projection fields and in regions associated with dopamine-containing cell bodies, suggesting both postsynaptic and presynaptic autoreceptor localization.
Journal Article
Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes.
Vida Asghari,O. Schoots,S. Van Kats,K. Ohara,Vera Jovanovic,Hong-Chang Guan,James R. Bunzow,A. Petronis,H. H. M. Van Tol +8 more
TL;DR: Comparisons of the pharmacological binding profiles of seven different polymorphic variants of the human D4 receptor, the rat D4 receptors, and two different human D3 receptor mutants suggest that the polymorphic repeat sequence has little influence on D4 binding profiles and might not be essential for G protein interaction.
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Molecular cloning and expression of the rat beta 1-adrenergic receptor gene.
Curtis A. Machida,James R. Bunzow,Robert P. Searles,H. H. M. Van Tol,B Tester,Kim A. Neve,P Teal,Valerie Nipper,Olivier Civelli +8 more
TL;DR: Genomic Southern blot and gene dosage analyses indicate that the rat beta 1-AR gene is a single copy gene, consistent with properties expected of the beta 2-AR subtype.