J
John T. Williams
Researcher at Oregon Health & Science University
Publications - 196
Citations - 19600
John T. Williams is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Dopamine & Inhibitory postsynaptic potential. The author has an hindex of 73, co-authored 188 publications receiving 18073 citations. Previous affiliations of John T. Williams include Massachusetts Institute of Technology & University of Portland.
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Journal ArticleDOI
Cellular and synaptic adaptations mediating opioid dependence.
TL;DR: A review on the adaptive changes in cellular and synaptic function induced by chronic morphine treatment can be found in this article, where the initial steps of opioid action are mediated through the activation of G protein-linked receptors.
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Nicotine activates and desensitizes midbrain dopamine neurons
TL;DR: It is shown that the same concentration of nicotine achieved by smokers activates and desensitizes multiple nicotinic receptors thereby regulating the activity of mesolimbic dopamine neurons, which could mediate the rewarding aspects of tobacco use.
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Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
Tommaso Patriarchi,Jounhong Ryan Cho,Katharina Merten,Mark W. Howe,Aaron Marley,Wei Hong Xiong,Robert W. Folk,Gerard Joey Broussard,Ruqiang Liang,Min Jee Jang,Haining Zhong,Daniel A. Dombeck,Mark von Zastrow,Axel Nimmerjahn,Viviana Gradinaru,John T. Williams,Lin Tian +16 more
TL;DR: The development and validation of dLight1 is reported, a novel suite of intensity-based genetically encoded dopamine indicators that enables ultrafast optical recording of neuronal dopamine dynamics in behaving mice and permits robust detection of physiologically and behaviorally relevant dopamine transients.
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Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.
John T. Williams,Susan L. Ingram,Graeme Henderson,Charles Chavkin,Mark von Zastrow,Stefan Schulz,Thomas Koch,Christopher J. Evans,MacDonald J. Christie +8 more
TL;DR: There are large gaps in understanding the molecular processes responsible for loss of MOR function after chronic exposure to opioids, and further elucidation of the cellular mechanisms that are regulated by opioids will be necessary for the successful development of MOR-based approaches to new pain therapeutics that limit the development of tolerance.
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Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type
James R. Bunzow,Carmen Sáez,Marty Mortrud,Claudia Bouvier,John T. Williams,Malcolm J. Low,David K. Grandy,David K. Grandy +7 more
TL;DR: In situ hybridization analysis revealed that LC132 mRNA is highly expressed in several rat brain areas, including the cerebral cortex, thalamus, subfornical organ, habenula, hypothalamus, central gray, dorsal raphe, locus coeruleus and the dorsal horn of the spinal cord.