M
Malcolm J. Low
Researcher at University of Michigan
Publications - 208
Citations - 25954
Malcolm J. Low is an academic researcher from University of Michigan. The author has contributed to research in topics: Proopiomelanocortin & Receptor. The author has an hindex of 69, co-authored 206 publications receiving 24801 citations. Previous affiliations of Malcolm J. Low include Vollum Institute & Boston University.
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Journal ArticleDOI
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Michael A. Cowley,James L. Smart,Marcelo Rubinstein,Marcelo G. Cerdán,Sabrina Diano,Tamas L. Horvath,Roger D. Cone,Malcolm J. Low +7 more
TL;DR: An integrated model of leptin action and neuronal architecture in the arcuate nucleus of the hypothalamus is proposed and it is shown that melanocortin peptides have an autoinhibitory effect on this circuit.
Journal ArticleDOI
Gut hormone PYY 3-36 physiologically inhibits food intake
Rachel L. Batterham,Michael A. Cowley,Caroline J. Small,Herbert Herzog,Mark Cohen,C. L. Dakin,Alison M. Wren,Audrey E. Brynes,Malcolm J. Low,Mohammad A. Ghatei,Roger D. Cone,Stephen R. Bloom +11 more
TL;DR: In this paper, the authors showed that post-prandial elevation of PYY3-36 may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway.
Journal Article
BRIEF COMMUNICATION ARISING: Gut hormone PYY3-36 physiologically inhibits food intake
Rachel L. Batterham,Michael A. Cowley,Caroline J. Small,Herbert Herzog,Mark A Cohen,C. L. Dakin,Alison M. Wren,Audrey E. Brynes,Malcolm J. Low +8 more
TL;DR: The authors showed that post-prandial elevation of PYY3-36 may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway.
Journal ArticleDOI
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Michael A. Cowley,Roy G. Smith,Sabrina Diano,Matthias H. Tschöp,Nina Pronchuk,Kevin L. Grove,Christian J. Strasburger,Martin Bidlingmaier,Michael Esterman,Mark L. Heiman,Luis M. Garcia-Segura,Eduardo A. Nillni,Pablo Mendez,Malcolm J. Low,Péter Sótonyi,Jeffrey M. Friedman,Hongyan Liu,Shirly Pinto,William F. Colmers,Roger D. Cone,Tamas L. Horvath +20 more
TL;DR: Using electrophysiological recordings, ghrelin stimulated the activity of arcuate NPY neurons and mimicked the effect of NPY in the paraventricular nucleus of the hypothalamus (PVH), thus representing a novel regulatory circuit controlling energy homeostasis.
Journal ArticleDOI
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.
TL;DR: The high degree of conservation, distinct pharmacology, and unique neuronal distribution of the MC4 receptor suggest specific and complex roles for the melanocortin peptides in neuroendocrine and autonomic control.