J
James R. Hawker
Researcher at Texas A&M University
Publications - 19
Citations - 1161
James R. Hawker is an academic researcher from Texas A&M University. The author has contributed to research in topics: Cell culture & Endothelial stem cell. The author has an hindex of 14, co-authored 19 publications receiving 1133 citations. Previous affiliations of James R. Hawker include University of South Florida & Texas A&M University System.
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Journal ArticleDOI
Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells
Hui Li,Cynthia J. Meininger,James R. Hawker,Tony E. Haynes,Diane Kepka-Lenhart,Sanjay K. Mistry,Sidney M. Morris,Guoyao Wu +7 more
TL;DR: The results indicate that arginase expression can modulate NO synthesis in bovine venular EC and that basal levels of arginases I and II are limiting for endothelial syntheses of polyamines, proline, and glutamate and may have important implications for wound healing, angiogenesis, and cardiovascular function.
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Transforming growth factor-β inhibition of proteasomal activity: a potential mechanism of growth arrest
TL;DR: Growth inhibition by TGF-beta decreases a specific proteasomal activity via an HSP90-independent mechanism that may involve oxidative inactivation or modulation of proteasome subunit composition and results in altered cellular expression of key cell cycle regulatory proteins such as p27KIP1.
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Activities of arginase I and II are limiting for endothelial cell proliferation
TL;DR: DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, was used to establish that increased polyamine synthesis was involved in mediating the enhanced growth of AI-EC and AII-EC.
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FKBP-12 Recognition Is Dispensable For Signal Generation by Type I Transforming Growth Factor-β Receptors
TL;DR: FKBP12 recognition is dispensable for TGFβ signaling as the FK506 motif resembles an invariant Leu-Pro dipeptide in TβR-I, along with mutations across the Gly/Ser box.
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Venular endothelial cells from bovine heart.
TL;DR: The formation of vessel meshworks by the coronary venular endothelial cells provides an in vitro model for the study of coronary angiogenesis and can be utilized to examine mechanisms of water and protein transport across coronary venules.