J
James R. Runo
Researcher at University of Wisconsin-Madison
Publications - 15
Citations - 572
James R. Runo is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Pulmonary hypertension & Portopulmonary hypertension. The author has an hindex of 6, co-authored 15 publications receiving 433 citations. Previous affiliations of James R. Runo include University of Wisconsin Hospital and Clinics.
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Journal ArticleDOI
BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia
Whitney Wooderchak-Donahue,Jamie McDonald,Brendan D. O'Fallon,Paul D. Upton,Wei Li,Beth L. Roman,Sarah Young,Parker Plant,Gyula T. Fülöp,Carmen Langa,Nicholas W. Morrell,Luisa María Botella,Carmelo Bernabeu,David A. Stevenson,James R. Runo,Pinar Bayrak-Toydemir +15 more
TL;DR: The genetic etiology for 191 unrelated individuals clinically suspected to have HHT was investigated with the use of exome and Sanger sequencing and bmp9-deficient zebrafish model demonstrated that BMP9 is involved in angiogenesis, confirming a genetic cause of a vascular-anomaly syndrome that has phenotypic overlap with HHT.
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Multidisciplinary approach to cardiac and pulmonary vascular disease risk assessment in liver transplantation: An evaluation of the evidence and consensus recommendations
Lisa B. VanWagner,Matthew E. Harinstein,James R. Runo,Christopher Darling,Marina Serper,Shelley A. Hall,Jon A. Kobashigawa,Laura L. Hammel +7 more
TL;DR: A critical assessment of the diagnosis of cardiac and pulmonary vascular disease and interventions aimed at managing these conditions in LT candidates is provided to offer guidance for clinicians and identify gaps in knowledge for future investigations.
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Treatment with sildenafil and treprostinil allows successful liver transplantation of patients with moderate to severe portopulmonary hypertension
Trina Hollatz,Alexandru I. Musat,Susanne Westphal,Catherine Decker,Anthony M. D'Alessandro,Jon G. Keevil,Li Zhanhai,James R. Runo +7 more
TL;DR: An aggressive approach to the treatment of PoPH with sildenafil and/or treprostinil and subsequent liver transplantation may be curative for PoPH in some patients.
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Mosaic ACVRL1 and ENG mutations in hereditary haemorrhagic telangiectasia patients
D. Hunter Best,Cecily P. Vaughn,Jamie McDonald,Kristy Damjanovich,James R. Runo,Jason M Chibuk,Pinar Bayrak-Toydemir +6 more
TL;DR: Two patients with no family history of HHT and strikingly different clinical presentations, who are mosaic for mutations in the ACVRL1 or ENG gene, are reported here, which represents the first report of mosaicism in patients clinically affected with classical H HT and pulmonary arterial hypertension.
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Magnetic Resonance and Computed Tomography Imaging of the Structural and Functional Changes of Pulmonary Arterial Hypertension
Mark L. Schiebler,Sanjeev Bhalla,James R. Runo,Nizar N. Jarjour,Alejandro Roldan,Naomi C. Chesler,Christopher J. François +6 more
TL;DR: Although features that are indirectly related to PAH are found on noninvasive imaging studies, its diagnosis and management still require right heart catheterization, andUntreated PAH frequently results in rapid clinical decline and death within 3 years of diagnosis.