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Nizar N. Jarjour
Researcher at University of Wisconsin-Madison
Publications - 275
Citations - 18306
Nizar N. Jarjour is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Asthma & Eosinophil. The author has an hindex of 64, co-authored 239 publications receiving 15437 citations. Previous affiliations of Nizar N. Jarjour include National Jewish Health & University of Rochester.
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Journal ArticleDOI
Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program
Wendy C. Moore,Deborah A. Meyers,Sally E. Wenzel,W. Gerald Teague,Huashi Li,Xingnan Li,Ralph B. D'Agostino,Mario Castro,Douglas Curran-Everett,Anne M. Fitzpatrick,Benjamin Gaston,Nizar N. Jarjour,Ronald L. Sorkness,William J. Calhoun,Kian Fan Chung,Suzy A.A. Comhair,Raed A. Dweik,Elliot Israel,Stephen P. Peters,William W. Busse,Serpil C. Erzurum,Eugene R. Bleecker +21 more
TL;DR: Five distinct clinical phenotypes of asthma have been identified using an unsupervised hierarchical cluster analysis, which supports clinical heterogeneity in asthma and the need for new approaches for the classification of disease severity in asthma.
Journal ArticleDOI
Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: A multicenter, randomized, double-blind, sham-controlled clinical trial
Mario Castro,Adalberto Sperb Rubin,Michel Laviolette,Jussara Fiterman,Marina Andrade Lima,Pallav L. Shah,Elie Fiss,Ronald Olivenstein,Neil C. Thomson,Robert Niven,Ian D. Pavord,Michael Simoff,David Duhamel,Charlene McEvoy,Richard G. Barbers,Nicolaas H T Ten Hacken,Michael E. Wechsler,Mark Holmes,Martin J. Phillips,Serpil C. Erzurum,William Lunn,Elliot Israel,Nizar N. Jarjour,Monica Kraft,Narinder S. Shargill,John Quiring,Scott M. Berry,Gerard Cox +27 more
TL;DR: BT in subjects with severe asthma improves asthma-specific quality of life with a reduction in severe exacerbations and healthcare use in the posttreatment period, and is superior in the BT group compared with sham.
Journal ArticleDOI
Effects of Treatment with Anti-immunoglobulin E Antibody Omalizumab on Airway Inflammation in Allergic Asthma
Ratko Djukanovic,Susan J. Wilson,Monica Kraft,Nizar N. Jarjour,Mark D. Steel,K. Fan Chung,Weibin Bao,Angel FowlerTaylor,John G. Matthews,William W. Busse,Stephen T. Holgate,John V. Fahy +11 more
TL;DR: The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to Methacholine in mild to moderate asthma.
Journal ArticleDOI
A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma
Geoffrey L. Chupp,Chun Geun Lee,Nizar N. Jarjour,Yun M. Shim,Carole Holm,Susan He,James Dziura,Jennifer L. Reed,Anthony J. Coyle,Peter A. Kiener,Mark R. Cullen,Martine Grandsaigne,Marie-Christine Dombret,Michel Aubier,Marina Pretolani,Jack A. Elias +15 more
TL;DR: YKL-40 is found in increased quantities in the serum and lungs in a subgroup of patients with asthma, in whom expression of chitinase in both compartments correlates with the severity of asthma.
Journal ArticleDOI
Tiotropium bromide step-up therapy for adults with uncontrolled asthma
Stephen P. Peters,Susan J. Kunselman,Nikolina Icitovic,Wendy C. Moore,Rodolfo M. Pascual,Bill T. Ameredes,Homer A. Boushey,William J. Calhoun,Mario Castro,Reuben M. Cherniack,Timothy J. Craig,Loren C. Denlinger,Linda Engle,Emily DiMango,John V. Fahy,Elliot Israel,Nizar N. Jarjour,Shamsah Kazani,Monica Kraft,Stephen C. Lazarus,Robert F. Lemanske,Njira L Lugogo,Richard J. Martin,Deborah A. Meyers,Joe W. Ramsdell,Christine A. Sorkness,E. Rand Sutherland,Stanley J. Szefler,Stephen I. Wasserman,Michael J. Walter,Michael E. Wechsler,Vernon M. Chinchilli,Eugene R. Bleecker +32 more
TL;DR: When added to an inhaled glucocorticoid, tiotropium improved symptoms and lung function in patients with inadequately controlled asthma and its effects appeared to be equivalent to those with the addition of salmeterol.