Showing papers by "James Sneyd published in 2009"
01 Jan 2009
TL;DR: Keener et al. as mentioned in this paper have published a book "Cellular Physiology al precio 56,81 € de Keener, James, Sneyd, and James, published by the tienda de libros de Medicina, Libros de Anatomia - Fisiologia humana.
Abstract: Tienda online donde Comprar Mathematical Physiology · I: Cellular Physiology al precio 56,81 € de Keener, James | Sneyd, James, tienda de Libros de Medicina, Libros de Anatomia - Fisiologia humana
113 citations
TL;DR: It is shown that the most complex time-dependent model that can be unambiguously determined from steady-state data is one with three closed states and one open state, and how the rate constants depend on calcium is determined.
52 citations
01 Jan 2009
TL;DR: In this article, Keener et al. present a collection of Libros de Medicina, Libros of Anatomia, and Fisiologia humana for the study of systems physics.
Abstract: Tienda online donde Comprar Mathematical Physiology · II: Systems Physiology al precio 64,79 € de Keener, James | Sneyd, James, tienda de Libros de Medicina, Libros de Anatomia - Fisiologia humana
49 citations
TL;DR: A model of the activated ASM strip is developed and it is speculated that this force decrement reflects some mechanism unrelated to the cycling of crossbridges, and which may be involved in the reversal of bronchoconstriction induced by a deep inflation of the lungs in vivo.
Abstract: Airway smooth muscle (ASM) is cyclically stretched during breathing, even in the active state, yet the factors determining its dynamic force-length behavior remain incompletely understood. We developed a model of the activated ASM strip and compared its behavior to that observed in strips of rat trachealis muscle stimulated with methacholine. The model consists of a nonlinear viscoelastic element (Kelvin body) in series with a force generator obeying the Hill force-velocity relationship. Isometric force in the model is proportional to the number of bound crossbridges, the attachment of which follows first-order kinetics. Crossbridges detach at a rate proportional to the rate of change of muscle length. The model accurately accounts for the experimentally observed transient and steady-state oscillatory force-length behavior of both passive and activated ASM. However, the model does not predict the sustained decrement in isometric force seen when activated strips of ASM are subjected briefly to large stretches. We speculate that this force decrement reflects some mechanism unrelated to the cycling of crossbridges, and which may be involved in the reversal of bronchoconstriction induced by a deep inflation of the lungs in vivo.
40 citations
TL;DR: This work illustrates a parameter estimation method based on Markov chain Monte Carlo, which can be used to fit directly to single-channel data, and shows that non-steady-state data is required to determine more complex models.
36 citations
TL;DR: This work studied the process of obstructed diffusion within the myofilament lattice using Monte Carlo simulation, level-set and homogenization theory to discover that the nonhomogeneous distribution in the troponin binding sites has no effect on the macroscopic Ca2+ dynamics.
35 citations
TL;DR: A model to investigate the effect of buffers with slow and fast reaction rates on single release spikes finds that, depending on their diffusion coefficient, fast buffers can either decouple clusters or delay inhibition of Ca(2+) release.
33 citations
TL;DR: This work describes the application of the Bayesian methods to real experimental single-channel data in three ion channels: the ryanodine receptor, the K(+) channel, and the IPR and discusses the modeling implications for single- channel data that display different levels of channel activity within one recording.
Abstract: The inositol trisphosphate receptor (IPR) plays an important role in controlling the dynamics of intracellular Ca(2+). Single-channel patch-clamp recordings are a typical way to study these receptors as well as other ion channels. Methods for analyzing and using this type of data have been developed to fit Markov models of the receptor. The usual method of parameter fitting is based on maximum-likelihood techniques. However, Bayesian inference and Markov chain Monte Carlo techniques are becoming more popular. We describe the application of the Bayesian methods to real experimental single-channel data in three ion channels: the ryanodine receptor, the K(+) channel, and the IPR. One of the main aims of all three studies was that of model selection with different approaches taken. We also discuss the modeling implications for single-channel data that display different levels of channel activity within one recording.
13 citations
01 Jan 2009
6 citations
01 Jan 2009
6 citations
01 Jan 2009
01 Apr 2009