J
Jamie Heimburg-Molinaro
Researcher at Beth Israel Deaconess Medical Center
Publications - 67
Citations - 2604
Jamie Heimburg-Molinaro is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Glycan & Antigen. The author has an hindex of 25, co-authored 59 publications receiving 2132 citations. Previous affiliations of Jamie Heimburg-Molinaro include University at Buffalo & State University of New York System.
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Journal ArticleDOI
Innate immune lectins kill bacteria expressing blood group antigen
Sean R. Stowell,Connie M. Arthur,Marcelo Dias-Baruffi,Lilian Cataldi Rodrigues,Jean-Philippe F. Gourdine,Jamie Heimburg-Molinaro,Tongzhong Ju,Ross J. Molinaro,Carlos A. Rivera-Marrero,Baoyun Xia,David F. Smith,Richard D. Cummings +11 more
TL;DR: Two innate immune lectins, galectin-4 (Gal-4) and Gal-8, which are expressed in the intestinal tract, recognize and kill human blood group antigen–expressing Escherichia coli while failing to alter the viability of other E. coli strains or other Gram-negative or Gram-positive organisms both in vitro and in vivo.
Journal ArticleDOI
Cancer Vaccines and Carbohydrate Epitopes
Jamie Heimburg-Molinaro,Michelle A. Lum,Geraldine V. Vijay,Miten Jain,Adel Almogren,Kate Rittenhouse-Olson +5 more
TL;DR: The role of each of the above mentioned carbohydrate antIGens in cancer growth and metastasis and vaccine attempts using these antigens will be described.
Journal ArticleDOI
Microbial glycan microarrays define key features of host-microbial interactions
Sean R. Stowell,Connie M. Arthur,Ryan McBride,Oren Berger,Nahid Razi,Jamie Heimburg-Molinaro,Lilian Cataldi Rodrigues,Jean-Philippe F. Gourdine,Alexander J. Noll,Stephan von Gunten,David F. Smith,Yuriy A. Knirel,James C. Paulson,Richard D. Cummings +13 more
TL;DR: It is discovered that several innate immune galectins show specific recognition of microbes that express self-like antigens, leading to direct killing of a broad range of Gram-negative and Gram-positive microbes.
Book ChapterDOI
Simple sugars to complex disease--mucin-type O-glycans in cancer.
TL;DR: Mucin-type O-glycan biosynthesis, altered mucin- type O- glycans in primary tumors, including mechanisms for structural changes and contributions to the tumor phenotype, and clinical approaches to detect and target altered O- Glycans for cancer treatment and management are described.
Journal ArticleDOI
Shotgun glycomics: a microarray strategy for functional glycomics
Xuezheng Song,Yi Lasanajak,Baoyun Xia,Jamie Heimburg-Molinaro,Jeanne M. Rhea,Hong Ju,Chunmei Zhao,Ross J. Molinaro,Richard D. Cummings,David F. Smith +9 more
TL;DR: This work focuses on glycosphingolipids, a class of glycoconjugates that is challenging to study, recognized by toxins, antibodies and GBPs, and derivatized GSLs extracted from cells with a heterobifunctional fluorescent tag suitable for covalent immobilization.