J
Jan Holmgren
Researcher at University of Gothenburg
Publications - 65
Citations - 10644
Jan Holmgren is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Cholera toxin & Cholera. The author has an hindex of 36, co-authored 65 publications receiving 10110 citations. Previous affiliations of Jan Holmgren include Lund University & International Centre for Diarrhoeal Disease Research, Bangladesh.
Papers
More filters
Journal ArticleDOI
Mucosal immunity and vaccines
Jan Holmgren,Cecil Czerkinsky +1 more
TL;DR: The properties of the mucosal immune system are reviewed and advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders are discussed.
Journal ArticleDOI
Evidence for several waves of global transmission in the seventh cholera pandemic
Ankur Mutreja,Dong Wook Kim,Dong Wook Kim,Nicholas R. Thomson,Thomas R. Connor,Jehee Lee,Jehee Lee,Samuel Kariuki,Nicholas J. Croucher,Seon Young Choi,Seon Young Choi,Simon R. Harris,Michael Lebens,Swapan Kumar Niyogi,Eun Jin Kim,Thandavarayan Ramamurthy,Jongsik Chun,James L. N. Wood,John D. Clemens,Cecil Czerkinsky,G. Balakrish Nair,Jan Holmgren,Julian Parkhill,Gordon Dougan +23 more
TL;DR: It is shown here that the seventh pandemic has spread from the Bay of Bengal in at least three independent but overlapping waves with a common ancestor in the 1950s, and several transcontinental transmission events are identified.
Journal ArticleDOI
Actions of cholera toxin and the prevention and treatment of cholera
TL;DR: The drastic intestinal secretion of fluid and electrolytes that is characteristic of cholera is the result of reasonably well understood cellular and biochemical actions of the toxin secreted by Vibrio cholerae.
Journal ArticleDOI
Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up
John D. Clemens,David A. Sack,Jeffrey R. Harris,F. P. L. Van Loon,Jyotsnamoy Chakraborty,Firoz Ahmed,M. R. Rao,M. R. Khan,Yunus,Nurul Huda,Bonita F. Stanton,Bradford A. Kay,R Eeckels,Stephen D. Walter,Ann-Mari Svennerholm,Jan Holmgren +15 more
TL;DR: Protection was similar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years than in older persons (63% for BS-WC; 68% for WC); and PE was substantially higher against classical cholero than against El Tor cholERA.
Journal ArticleDOI
Tissue receptor for cholera exotoxin: postulated structure from studies with GM1 ganglioside and related glycolipids.
TL;DR: The portion Gal --> GalNAc [Formula: see text] is identified as the critical region in G(M1) for toxin fixation, and it is postulated that this may be the tissue receptor structure for the cholera toxin.