T
Thomas R. Connor
Researcher at Cardiff University
Publications - 109
Citations - 15011
Thomas R. Connor is an academic researcher from Cardiff University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 40, co-authored 90 publications receiving 10581 citations. Previous affiliations of Thomas R. Connor include Wellcome Trust Sanger Institute & Harvard University.
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Journal ArticleDOI
A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers.
Michael A. Quail,Miriam Smith,Paul Coupland,Thomas D. Otto,Simon R. Harris,Thomas R. Connor,Anna Bertoni,Harold Swerdlow,Yong Gu +8 more
TL;DR: All three fast turnaround sequencers evaluated here were able to generate usable sequence, however there are key differences between the quality of that data and the applications it will support.
Journal ArticleDOI
Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using Gubbins.
Nicholas J. Croucher,Andrew J. Page,Thomas R. Connor,Aidan Delaney,Jacqueline A. Keane,Stephen D. Bentley,Julian Parkhill,Simon R. Harris +7 more
TL;DR: Gubbins is an iterative algorithm that uses spatial scanning statistics to identify loci containing elevated densities of base substitutions suggestive of horizontal sequence transfer while concurrently constructing a maximum likelihood phylogeny based on the putative point mutations outside these regions of high sequence diversity.
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Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health
Kathryn E. Holt,Heiman F. L. Wertheim,Ruth N. Zadoks,Stephen Baker,Chris A. Whitehouse,David A. B. Dance,Adam Jenney,Thomas R. Connor,Li Yang Hsu,Juliëtte A. Severin,Sylvain Brisse,Hanwei Cao,Jonathan J. Wilksch,Claire L. Gorrie,Mark B. Schultz,David J. Edwards,Kinh Van Nguyen,Trung Vu Nguyen,Trinh Tuyet Dao,Martijn Mensink,Vien Le Minh,Nguyen Thi Khanh Nhu,Constance Schultsz,Kuntaman Kuntaman,Paul N. Newton,Paul N. Newton,Catrin E. Moore,Catrin E. Moore,Richard A. Strugnell,Nicholas R. Thomson,Nicholas R. Thomson +30 more
TL;DR: The DNA sequence of K. pneumoniae isolates from around the world is determined and it is shown that there is a wide spectrum of diversity, including variation within shared sequences and gain and loss of whole genes, and there is an unrecognized association between the possession of specific gene profiles associated with virulence and antibiotic resistance.
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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
Erik M. Volz,Verity Hill,John T. McCrone,Anna Price,David Jorgensen,Áine O'Toole,Joel Southgate,Robert Johnson,Ben Jackson,Fabrícia F. Nascimento,Sara Rey,Samuel M. Nicholls,Rachel M. Colquhoun,Ana da Silva Filipe,James G Shepherd,David J Pascall,Rajiv Shah,Natasha Jesudason,Kathy Li,Ruth F. Jarrett,Nicole Pacchiarini,Matthew J. Bull,Lily Geidelberg,Igor Siveroni,Ian Goodfellow,Nicholas J. Loman,Oliver G. Pybus,David Robertson,E. Thomson,Andrew Rambaut,Thomas R. Connor +30 more
TL;DR: Investigation of the hypothesis for positive selection of Spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage.
Journal ArticleDOI
Emergence and global spread of epidemic healthcare-associated Clostridium difficile.
Miao He,Fabio Miyajima,Paul Roberts,Louise Ellison,Derek Pickard,Melissa J. Martin,Thomas R. Connor,Simon R. Harris,Derek Fairley,Kathleen B. Bamford,Kathleen B. Bamford,Stephanie d’Arc,Stephanie d’Arc,Jon S. Brazier,Derek J. Brown,J. E. Coia,Gill Douce,Dale N. Gerding,Heejung Kim,Tse Hsien Koh,Haru Kato,Mitsutoshi Senoh,Tom Louie,Stephen L. Michell,Emma Butt,Sharon J. Peacock,Nicholas M. Brown,Nicholas M. Brown,Thomas V. Riley,Glen Songer,Mark H. Wilcox,Munir Pirmohamed,Ed J. Kuijper,Peter M. Hawkey,Brendan W. Wren,Gordon Dougan,Julian Parkhill,Trevor D. Lawley +37 more
TL;DR: This analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system.