J
Jan Marian
Researcher at Duke University
Publications - 5
Citations - 451
Jan Marian is an academic researcher from Duke University. The author has contributed to research in topics: Gonadotropin-releasing hormone & Receptor. The author has an hindex of 5, co-authored 5 publications receiving 450 citations.
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Journal ArticleDOI
Gonadotropin-Releasing Hormone Action in the Pituitary: A Three Step Mechanism*
P. Michael Conn,Jan Marian,Michael K. McMillian,Judy Stern,Deloris C. Rogers,Mark Hamby,Anna Penna,Elton Grant +7 more
TL;DR: This review describes experiments that led to the development of this model and summarizes recent progress, and describes the mechanism of Ca2+ mobilization in response to GnRH and its precise locus of action.
Journal ArticleDOI
Binding of gonadotropin releasing hormone agonist to rat ovarian granulosa cells.
TL;DR: The presence of stereospecific, high affinity GnRH binding sites in the rat ovarian granulosa cells is demonstrated, demonstrating the possibility that these inhibitory actions of GnRH were mediated through specific receptors which recognize GnRH.
Journal ArticleDOI
The calcium requirement in GnRH-stimulated LH release is not mediated through a specific action on receptor binding.
Jan Marian,P. Michael Conn +1 more
TL;DR: The data suggest that the requirement for Ca +2 in GnRH-stimulated LH release is not mediated through a specific action of this ion at the level of receptor binding, and compounds which chelate cations increased specific binding of the ligand.
Journal ArticleDOI
Subcellular localization of the receptor for gonadotropin-releasing hormone in pituitary and ovarian tissue.
Jan Marian,P. Michael Conn +1 more
TL;DR: The data suggest that the GnRH-binding sites detected by radioligand binding assay in pituitaries of rats not previously exposed to GnRH are localized almost exclusively in the plasma membrane fraction.
Journal ArticleDOI
Evidence for calcium mediation of gonadotropin releasing hormone action in the pituitary
TL;DR: A line of evidence has developed which suggests that calcium (Ca 2+ ) may play a central role in GnRH stimulation of gonadotropin release from cultured rat pituitary cells.