Jan Simoni

TL;DR: Fruits and vegetables improve metabolic acidosis and reduce kidney injury in stage 4 CKD without producing hyperkalemia, and one year of fruits and vegetables or NaHCO3 yielded eGFR that was not different, was associated with higher-than-baseline PTCO2, and was associatedWith lower- than-Baseline urine indices of kidney injury.

TL;DR: It is shown that in hypertensive nephropathy, daily sodium bicarbonate is an effective kidney protective adjunct to blood pressure control along with angiotensin-converting enzyme inhibition.

TL;DR: Dietary alkali treatment of metabolic acidosis in CKD that is less severe than that for which KDOQI recommends therapy reduces kidney angiotensin II activity and preserves eGFR.

TL;DR: A reduction in dietary acid decreased kidney injury in patients with moderately reduced eGFR due to hypertensive nephropathy and that with fruits and vegetables was comparable to sodium bicarbonate, andruits and vegetables appear to be an effective kidney protective adjunct to blood pressure reduction and angiotensin-converting enzyme inhibition in hypertensive and possibly other nephrostathies.

TL;DR: It appears that sodium citrate is an effective kidney-protective adjunct to blood pressure reduction and angiotensin-converting enzyme inhibition in patients with hypertensive nephropathy and metabolic acidosis.