J
Jan Tilmann Vollrath
Researcher at Goethe University Frankfurt
Publications - 18
Citations - 913
Jan Tilmann Vollrath is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Lung injury & Medicine. The author has an hindex of 6, co-authored 13 publications receiving 377 citations.
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Journal ArticleDOI
Cytokines in Inflammatory Disease.
TL;DR: This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines, focusing on the correlations and role of these inflammatory mediators in the genesis of inflammatory impacts.
Journal ArticleDOI
Endogenous Uteroglobin as Intrinsic Anti-inflammatory Signal Modulates Monocyte and Macrophage Subsets Distribution Upon Sepsis Induced Lung Injury.
Andrea Janicova,Nils Becker,Baolin Xu,Sebastian Wutzler,Jan Tilmann Vollrath,Frank Hildebrand,Sabrina Ehnert,Ingo Marzi,Philipp Störmann,Borna Relja +9 more
TL;DR: In in vitro experiments, the influence of uteroglobin on monocyte functions including migratory behavior, TGF-β1 expression, cytotoxicity and viability were proven and highlight an important role of endogenous uteroglobin as intrinsic anti-inflammatory signal upon sepsis-induced early lung injury, which modules the early monocyte/macrophages driven inflammation.
Journal ArticleDOI
miR-142-3p Expression Is Predictive for Severe Traumatic Brain Injury (TBI) in Trauma Patients.
Cora R Schindler,Mathias Woschek,Jan Tilmann Vollrath,Kerstin Kontradowitz,Thomas Lustenberger,Philipp Störmann,Ingo Marzi,Dirk Henrich +7 more
TL;DR: In this article, the authors investigated promising microRNAs (miRNA) released from affected tissue after severe trauma that have predictive values for the effects of the injury and found that miR-423-3p expression is significantly elevated after isolated traumatic brain injury and predictable for severe TBI in the first hours after trauma.
Journal ArticleDOI
Post-Traumatic Sepsis Is Associated with Increased C5a and Decreased TAFI Levels
Jan Tilmann Vollrath,Ingo Marzi,Anna Herminghaus,Thomas Lustenberger,Borna Relja,Borna Relja +5 more
TL;DR: Both elevated C5a and decreased TAFI may serve as promising predictive factors for the development of sepsis after polytrauma and have confirmed their potential as early sepsi biomarkers.
Journal ArticleDOI
Early Local Inhibition of Club Cell Protein 16 Following Chest Trauma Reduces Late Sepsis-Induced Acute Lung Injury.
Philipp Störmann,Nils Becker,Jan Tilmann Vollrath,Kernt Köhler,Andrea Janicova,Sebastian Wutzler,Frank Hildebrand,Ingo Marzi,Borna Relja +8 more
TL;DR: The data confirmed the anti-inflammatory potential of endogenous CC16 in the murine double-hit model of ALI and confirmed that early CC16-neutralization increased the neutrophilic infiltration and lung injury at 6 h post-CLP, while 24 h later, the lung injury was reduced.