J
Jan Tkadlec
Researcher at Charles University in Prague
Publications - 25
Citations - 207
Jan Tkadlec is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Medicine & Staphylococcus aureus. The author has an hindex of 8, co-authored 20 publications receiving 124 citations.
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Journal ArticleDOI
The emergence of Clostridium difficile PCR ribotype 078 in piglets in the Czech Republic clusters with Clostridium difficile PCR ribotype 078 isolates from Germany, Japan and Taiwan.
Marcela Krutova,Monika Zouharova,Jana Matejkova,Jan Tkadlec,Josef Krejci,Martin Faldyna,Otakar Nyc,Jan Bernardy +7 more
TL;DR: This study found an emergence of C. difficile RT078 in Czech piglets that was related genetically to C.difficileRT078 from Germany, Japan and Taiwan.
Journal ArticleDOI
Antibiotic profiling of Clostridium difficile ribotype 176--A multidrug resistant relative to C. difficile ribotype 027.
TL;DR: Accumulation of resistance mechanisms to multiple antibiotics highlight that PCR-ribotype 176 belong to problematic epidemic strains of Clostridium difficile.
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The use of broad-range bacterial PCR in the diagnosis of infectious diseases: a prospective cohort study.
Jan Tkadlec,M. Peckova,L. Sramkova,Vilém Rohn,D. Jahoda,D. Raszka,J. Berousek,F. Mosna,Tomas Vymazal,M. Kvapil,Pavel Drevinek +10 more
TL;DR: Broad-range PCR substantially increases detection rate of pathogens, especially from heart valves and joint samples, however, a concurrent risk of false-negative PCR results justifies the need for parallel culture.
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Environmental Stress Affects the Formation of Staphylococcus aureus Persisters Tolerant to Antibiotics.
TL;DR: It is demonstrated that both stress and antibiotic exposure increase the expression of SigB in bacterial populations from very early on and that the expression level of sigB differs with the type of antibiotic and stress, but no correlation was observed between persister formation and sigB expression.
Journal ArticleDOI
Cutaneous bacillary angiomatosis due to Bartonella quintana in a renal transplant recipient.
Jiri Orsag,Patrik Flodr,Oto Melter,Jan Tkadlec,Jan Sternbersky,Miroslav Hruby,Anna Klicova,Kamil Zamboch,Karel Krejčí,Josef Zadrazil +9 more
TL;DR: It is demonstrated that BA should be considered a differential diagnosis in immunocompromised patients presenting with fever and cutaneous angioma‐like lesions and should be treated with antibiotics because of potentially life‐threatening course of the disease.