J
Jan-Willem Lankhaar
Researcher at VU University Medical Center
Publications - 12
Citations - 2327
Jan-Willem Lankhaar is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Pulmonary hypertension & Vascular resistance. The author has an hindex of 9, co-authored 12 publications receiving 2032 citations.
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Journal ArticleDOI
The arterial Windkessel
TL;DR: Characteristic impedance was introduced as a third element of the Windkessel model, a lumped model not suitable for the assessment of spatially distributed phenomena and aspects of wave travel, but it is a simple and fairly accurate approximation of ventricular afterload.
Journal ArticleDOI
Noninvasively Assessed Pulmonary Artery Stiffness Predicts Mortality in Pulmonary Arterial Hypertension
C. Tji-Joong Gan,Jan-Willem Lankhaar,Nico Westerhof,J. Tim Marcus,Annemarie Becker,Jos W. R. Twisk,Anco Boonstra,Pieter E. Postmus,Anton Vonk-Noordegraaf +8 more
TL;DR: Noninvasively measured pulmonary artery RAC predicted mortality better than area distensibility in patients with PAH, and showed an inverse curvilinear relation with mean pulmonary artery pressure.
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Quantification of right ventricular afterload in patients with and without pulmonary hypertension.
Jan-Willem Lankhaar,Nicolaas Westerhof,Theo J.C. Faes,Koen M. Marques,J. Tim Marcus,P E Postmus,Anton Vonk-Noordegraaf +6 more
TL;DR: The results show that differences in RV afterload among groups with different forms of PH can be quantified with a windkessel model and suggest that the RC time and the elastic properties of the large pulmonary arteries remain unchanged in PH.
Journal ArticleDOI
Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension.
C. Tji-Joong Gan,Jan-Willem Lankhaar,J. Tim Marcus,Nico Westerhof,Koen M. Marques,Jean G.F. Bronzwaer,Anco Boonstra,Pieter E. Postmus,Anton Vonk-Noordegraaf +8 more
TL;DR: In PAH patients, ventricular interaction mediated by the interventricular septum impairs left ventricular filling, contributing to decreased stroke volume.
Journal ArticleDOI
Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension
Jan-Willem Lankhaar,Nico Westerhof,Theo J.C. Faes,C. Tji-Joong Gan,Koen M. Marques,Anco Boonstra,Fred G. van den Berg,Pieter E. Postmus,Anton Vonk-Noordegraaf +8 more
TL;DR: During therapy for PH, R and C remain inversely related and changes in both R andC better explain changes in cardiac index than either of them alone.