C
C. Tji-Joong Gan
Researcher at VU University Medical Center
Publications - 13
Citations - 2125
C. Tji-Joong Gan is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Pulmonary hypertension & Diastole. The author has an hindex of 10, co-authored 12 publications receiving 1911 citations.
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Journal ArticleDOI
Noninvasively Assessed Pulmonary Artery Stiffness Predicts Mortality in Pulmonary Arterial Hypertension
C. Tji-Joong Gan,Jan-Willem Lankhaar,Nico Westerhof,J. Tim Marcus,Annemarie Becker,Jos W. R. Twisk,Anco Boonstra,Pieter E. Postmus,Anton Vonk-Noordegraaf +8 more
TL;DR: Noninvasively measured pulmonary artery RAC predicted mortality better than area distensibility in patients with PAH, and showed an inverse curvilinear relation with mean pulmonary artery pressure.
Journal ArticleDOI
Interventricular Mechanical Asynchrony in Pulmonary Arterial Hypertension Left-to-Right Delay in Peak Shortening Is Related to Right Ventricular Overload and Left Ventricular Underfilling
J. Tim Marcus,C. Tji-Joong Gan,Jaco J.M. Zwanenburg,Anco Boonstra,Cor Allaart,Marco J.W. Götte,Anton Vonk-Noordegraaf +6 more
TL;DR: In PAH, the L-R delay in myocardial peak shortening is caused by lengthening of the duration of RV shortening, which is related to LVSB, decreased LV filling, and decreased stroke volume.
Journal ArticleDOI
Right ventricular diastolic impairment in patients with pulmonary arterial hypertension
Silvia Rain,M. Louis Handoko,Pia Trip,C. Tji-Joong Gan,Nico Westerhof,Ger J.M. Stienen,Walter Paulus,Coen A.C. Ottenheijm,J. Tim Marcus,Peter Dorfmüller,Christophe Guignabert,Marc Humbert,Peter S. Macdonald,Cris dos Remedios,P E Postmus,Chandra Saripalli,Carlos Hidalgo,Henk Granzier,Anton Vonk-Noordegraaf,Jolanda van der Velden,Frances S. de Man +20 more
TL;DR: RV diastolic stiffness is significantly increased in PAH patients, with important contributions from increased collagen and intrinsic stiffening of the RV cardiomyocyte sarcomeres and titin phosphorylation.
Journal ArticleDOI
Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension.
C. Tji-Joong Gan,Jan-Willem Lankhaar,J. Tim Marcus,Nico Westerhof,Koen M. Marques,Jean G.F. Bronzwaer,Anco Boonstra,Pieter E. Postmus,Anton Vonk-Noordegraaf +8 more
TL;DR: In PAH patients, ventricular interaction mediated by the interventricular septum impairs left ventricular filling, contributing to decreased stroke volume.
Journal ArticleDOI
Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension
Jan-Willem Lankhaar,Nico Westerhof,Theo J.C. Faes,C. Tji-Joong Gan,Koen M. Marques,Anco Boonstra,Fred G. van den Berg,Pieter E. Postmus,Anton Vonk-Noordegraaf +8 more
TL;DR: During therapy for PH, R and C remain inversely related and changes in both R andC better explain changes in cardiac index than either of them alone.