J
J. Tim Marcus
Researcher at VU University Amsterdam
Publications - 103
Citations - 7518
J. Tim Marcus is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Pulmonary hypertension & Stroke volume. The author has an hindex of 43, co-authored 99 publications receiving 6727 citations. Previous affiliations of J. Tim Marcus include VU University Medical Center.
Papers
More filters
Journal ArticleDOI
Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy.
Mariëlle C. van de Veerdonk,Taco Kind,J. Tim Marcus,Gert-Jan Mauritz,Martijn W. Heymans,Harm-Jan Bogaard,Harm-Jan Bogaard,Anco Boonstra,Koen M. Marques,Nico Westerhof,Anton Vonk-Noordegraaf +10 more
TL;DR: After PAH-targeted therapy, RV function can deteriorate despite a reduced PVR, and loss of RV function is associated with a poor outcome, irrespective of any changes in PVR.
Journal ArticleDOI
Noninvasively Assessed Pulmonary Artery Stiffness Predicts Mortality in Pulmonary Arterial Hypertension
C. Tji-Joong Gan,Jan-Willem Lankhaar,Nico Westerhof,J. Tim Marcus,Annemarie Becker,Jos W. R. Twisk,Anco Boonstra,Pieter E. Postmus,Anton Vonk-Noordegraaf +8 more
TL;DR: Noninvasively measured pulmonary artery RAC predicted mortality better than area distensibility in patients with PAH, and showed an inverse curvilinear relation with mean pulmonary artery pressure.
Journal ArticleDOI
Interventricular Mechanical Asynchrony in Pulmonary Arterial Hypertension Left-to-Right Delay in Peak Shortening Is Related to Right Ventricular Overload and Left Ventricular Underfilling
J. Tim Marcus,C. Tji-Joong Gan,Jaco J.M. Zwanenburg,Anco Boonstra,Cor Allaart,Marco J.W. Götte,Anton Vonk-Noordegraaf +6 more
TL;DR: In PAH, the L-R delay in myocardial peak shortening is caused by lengthening of the duration of RV shortening, which is related to LVSB, decreased LV filling, and decreased stroke volume.
Journal ArticleDOI
Quantification of right ventricular afterload in patients with and without pulmonary hypertension.
Jan-Willem Lankhaar,Nicolaas Westerhof,Theo J.C. Faes,Koen M. Marques,J. Tim Marcus,P E Postmus,Anton Vonk-Noordegraaf +6 more
TL;DR: The results show that differences in RV afterload among groups with different forms of PH can be quantified with a windkessel model and suggest that the RC time and the elastic properties of the large pulmonary arteries remain unchanged in PH.
Journal ArticleDOI
Right ventricular diastolic impairment in patients with pulmonary arterial hypertension
Silvia Rain,M. Louis Handoko,Pia Trip,C. Tji-Joong Gan,Nico Westerhof,Ger J.M. Stienen,Walter Paulus,Coen A.C. Ottenheijm,J. Tim Marcus,Peter Dorfmüller,Christophe Guignabert,Marc Humbert,Peter S. Macdonald,Cris dos Remedios,P E Postmus,Chandra Saripalli,Carlos Hidalgo,Henk Granzier,Anton Vonk-Noordegraaf,Jolanda van der Velden,Frances S. de Man +20 more
TL;DR: RV diastolic stiffness is significantly increased in PAH patients, with important contributions from increased collagen and intrinsic stiffening of the RV cardiomyocyte sarcomeres and titin phosphorylation.