B
Bouke C. de Jong
Researcher at Institute of Tropical Medicine Antwerp
Publications - 119
Citations - 6358
Bouke C. de Jong is an academic researcher from Institute of Tropical Medicine Antwerp. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 34, co-authored 99 publications receiving 5521 citations. Previous affiliations of Bouke C. de Jong include Université catholique de Louvain & Medical Research Council.
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Journal ArticleDOI
Variable host-pathogen compatibility in Mycobacterium tuberculosis.
Sebastien Gagneux,Kathryn DeRiemer,Tran Van,Midori Kato-Maeda,Bouke C. de Jong,Sujatha Narayanan,Mark P. Nicol,Stefan Niemann,Kristin Kremer,M. Cristina Gutierrez,Markus Hilty,Philip C. Hopewell,Peter M. Small +12 more
TL;DR: It is demonstrated that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations, and in an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatrics than in allopatric patient populations.
Journal ArticleDOI
A Four-Month Gatifloxacin-Containing Regimen for Treating Tuberculosis
Corinne Merle,Katherine Fielding,Omou Bah Sow,M. Gninafon,Mame B. Lo,Thuli Mthiyane,Joseph Odhiambo,Evans Amukoye,Boubacar Bah,Ferdinand Kassa,Roxana Rustomjee,Bouke C. de Jong,John R. Horton,Christian Perronne,Charalambos Sismanidis,Olivier Lapujade,Piero Olliaro,Christian Lienhardt,Abstr Act +18 more
TL;DR: Noninferiority of the 4-month regimen to the standard regimen with respect to the primary efficacy end point was not shown, and there was no evidence of increased risks of prolongation of the QT interval or dysglycemia with the 4 month regimen.
Journal ArticleDOI
Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline
Koen Andries,Cristina Villellas,Nele Coeck,Kim Thys,Tom Gevers,Luc Vranckx,Nacer Lounis,Bouke C. de Jong,Anil Koul +8 more
TL;DR: It is reported that non-target based resistance to BDQ, and cross-resistance to clofazimine (CFZ), is due to mutations in Rv0678, a transcriptional repressor of the genes encoding the MmpS5-MmpL5 efflux pump.
Journal ArticleDOI
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
David Stucki,David Stucki,Daniela Brites,Daniela Brites,Leïla Jeljeli,Mireia Coscolla,Mireia Coscolla,Qingyun Liu,Andrej Trauner,Andrej Trauner,Lukas Fenner,Lukas Fenner,Lukas Fenner,Liliana K. Rutaihwa,Liliana K. Rutaihwa,Sonia Borrell,Sonia Borrell,Tao Luo,Qian Gao,Midori Kato-Maeda,Marie Ballif,Marie Ballif,Marie Ballif,Matthias Egger,Rita Macedo,Helmi Mardassi,Milagros Moreno,Griselda Tudo Vilanova,Janet A. M. Fyfe,Maria Globan,Jackson Thomas,Frances B. Jamieson,Jennifer L. Guthrie,Adwoa Asante-Poku,Dorothy Yeboah-Manu,Eddie M. Wampande,Willy Ssengooba,Willy Ssengooba,Moses Joloba,W. Henry Boom,Indira Basu,James E. Bower,Margarida Saraiva,Sidra Ezidio Gonçalves Vasconcellos,Philip Noel Suffys,Anastasia Koch,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Linda Gail-Bekker,Bijaya Malla,Bijaya Malla,Serej D. Ley,Serej D. Ley,Serej D. Ley,Hans-Peter Beck,Hans-Peter Beck,Bouke C. de Jong,Kadri Toit,Elisabeth Sanchez-Padilla,Maryline Bonnet,Ana Gil-Brusola,Matthias Frank,Véronique Penlap Beng,Kathleen D. Eisenach,Issam Alani,Perpetual Wangui Ndung'u,Gunturu Revathi,Florian Gehre,Florian Gehre,Suriya Akter,Francine Ntoumi,Lynsey Stewart-Isherwood,Nyanda E. Ntinginya,Andrea Rachow,Michael Hoelscher,Daniela Maria Cirillo,Girts Skenders,Sven Hoffner,Daiva Bakonyte,Petras Stakenas,Roland Diel,Valeriu Crudu,Olga Domnica Moldovan,Sahal Al-Hajoj,Larissa Otero,Francesca Barletta,E. Jane Carter,E. Jane Carter,Lameck Diero,Philip Supply,Iñaki Comas,Stefan Niemann,Sebastien Gagneux,Sebastien Gagneux +94 more
TL;DR: It is shown that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists, and further support a European origin for the most common generalist sublineage.
Journal ArticleDOI
Progression to Active Tuberculosis, but Not Transmission, Varies by Mycobacterium tuberculosis Lineage in The Gambia
Bouke C. de Jong,Philip C. Hill,Alex Aiken,Timothy Awine,Martin Antonio,Ifedayo M. O. Adetifa,Dolly Jackson-Sillah,Annette Fox,Kathryn DeRiemer,Sebastien Gagneux,Martien W. Borgdorff,Keith P. W. J. McAdam,Tumani Corrah,Peter M. Small,Richard A. Adegbola +14 more
TL;DR: The variable rate of progression by lineage suggests that tuberculosis variability matters in clinical settings and should be accounted for in studies evaluating tuberculosis vaccines and treatment regimens for latent tuberculosis infection.