Jana Staňková

TL;DR: It is reported that IL-13 up-regulates Cys LT1R mRNA levels, with consequently enhanced CysLT1R protein expression and function in human monocytes and monocyte-derived macrophages, and thus contribute to the pathogenesis of asthma and allergic diseases.

TL;DR: Receptor sequestration and ligand uptake was, at least in part, blocked by concanavalin A and blockers of endocytosis mediated by clathrin-coated pits and the C terminus tail of hPAFR, but not the putative internalization motifs, may be involved in the internalization of h PAFR.

TL;DR: It is reported that mutant GPCR can affect the functional properties of the co-expressed wild type (WT) receptor, and these findings could be extended to other GPCRs by showing that co-expression of the WT C-C chemokine receptor 2b with a carboxyl-terminal deletion mutant (K311stop), resulted in a decreased affinity and responsiveness to MCP-1.

TL;DR: The results indicate that ligand-induced PAFR internalization is dependent on arrestins, that PAFR can associate with both arrestin-2 and -3, and that their translocation involves interaction with the region of residues 318–330 in the PAFR C terminus but is independent of G-protein activation.

TL;DR: The results indicate that PAF activates Jak2 and that Tyk2 and the C-terminal tail of PAFR are of critical importance for PAF-induced Jak2 activation.