Jane E. Preston

TL;DR: It is proposed that new work and key historical studies both support the concept of a perivascular fluid system, whereby CSF enters the brain via PVS convective flow or dispersion along larger caliber arteries/arterioles, and diffusion predominantly regulates CSF/ISF exchange at the level of the neurovascular unit associated with CNS microvessels.

TL;DR: The understanding of the mechanisms that underlie the dysfunction of the CP-CSF system in the elderly may help discover the treatments needed to reverse the negative effects of aging that lead to global CNS failure.

TL;DR: It is demonstrated that the chemotactic behavior of these nanoswimmers, in combination with LRP-1 (low-density lipoprotein receptor–related protein 1) targeting, enables a fourfold increase in penetration to the brain compared to nonchemotactic systems.

TL;DR: The evidence for age‐related changes to the CP‐CSF system is reviewed and changes with disease states where appropriate are compared, including reduced ion transport capabilities, evidence for oxidative stress, altered hormone interactions, decreased CSF secretion rates in animal models and the contradictory nature of human data.

TL;DR: It is proposed that carnosine or related structures should be explored for possible intervention in pathologies that involve deleterious aldehydes, for example, secondary diabetic complications, inflammatory phenomena, alcoholic liver disease, and possibly Alzheimer's disease.