J
Jane E. Visvader
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 224
Citations - 32539
Jane E. Visvader is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 73, co-authored 215 publications receiving 29698 citations. Previous affiliations of Jane E. Visvader include Salk Institute for Biological Studies & University of Melbourne.
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Journal ArticleDOI
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
TL;DR: The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours.
Journal ArticleDOI
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
Michael F. Clarke,John E. Dick,Peter B. Dirks,Connie J. Eaves,Catriona Jamieson,D. Leanne Jones,Jane E. Visvader,Irving L. Weissman,Geoffrey M. Wahl +8 more
TL;DR: A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression, and participants were charged with evaluating data suggesting that cancers develop from a small subset of cells with self-renewal properties analogous to organ regeneration.
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Generation of a functional mammary gland from a single stem cell
Mark Shackleton,Mark Shackleton,François Vaillant,François Vaillant,Kaylene J. Simpson,Kaylene J. Simpson,John Stingl,Gordon K. Smyth,Marie Liesse Asselin-Labat,Marie Liesse Asselin-Labat,Li Wu,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Jane E. Visvader,Jane E. Visvader +14 more
TL;DR: It is shown that a single cell, marked with a LacZ transgene, can reconstitute a complete mammary gland in vivo and establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs.
Journal Article
Generation of a functional mammary gland from a single stem cell
Mark Shackleton,François Vaillant,Kaylene J. Simpson,John Stingl,Gordon K. Smyth,Marie Liesse Asselin-Labat,Li Wu,Jane E. Visvader,Geoffrey J. Lindeman +8 more
TL;DR: In this article, the mammary gland can be functionally regenerated in mice by serial transplantation of epithelial fragments, providing evidence for the existence of self-renewing, multipotential mammary stem cells (MaSCs).
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Cells of origin in cancer
TL;DR: Evidence is also accumulating that cancers of distinct subtypes within an organ may derive from different 'cells of origin', and the identification of these crucial target cell populations may allow earlier detection of malignancies and better prediction of tumour behaviour.