P
Peter B. Dirks
Researcher at University of Toronto
Publications - 288
Citations - 37596
Peter B. Dirks is an academic researcher from University of Toronto. The author has contributed to research in topics: Stem cell & Cancer. The author has an hindex of 69, co-authored 252 publications receiving 32672 citations. Previous affiliations of Peter B. Dirks include Hospital for Sick Children & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Identification of human brain tumour initiating cells
Sheila K. Singh,Cynthia Hawkins,Ian D. Clarke,Jeremy A. Squire,Jane Bayani,Takuichiro Hide,R. Mark Henkelman,Michael D. Cusimano,Peter B. Dirks +8 more
TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
Journal Article
Identification of a Cancer Stem Cell in Human Brain Tumors
Sheila K. Singh,Ian D. Clarke,Mizuhiko Terasaki,Victoria E. Bonn,Cynthia Hawkins,Jeremy A. Squire,Peter B. Dirks +6 more
TL;DR: The identification and purification of a cancer stem cell from human brain tumors of different phenotypes that possesses a marked capacity for proliferation, self-renewal, and differentiation is reported.
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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
Michael F. Clarke,John E. Dick,Peter B. Dirks,Connie J. Eaves,Catriona Jamieson,D. Leanne Jones,Jane E. Visvader,Irving L. Weissman,Geoffrey M. Wahl +8 more
TL;DR: A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression, and participants were charged with evaluating data suggesting that cancers develop from a small subset of cells with self-renewal properties analogous to organ regeneration.
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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
Traver Hart,Megha Chandrashekhar,Michael Aregger,Zachary Steinhart,Kevin R. Brown,Graham MacLeod,Monika Mis,Michal Zimmermann,Amélie Fradet-Turcotte,Song Sun,Patricia Mero,Peter B. Dirks,Sachdev S. Sidhu,Frederick P. Roth,Olivia S. Rissland,Daniel Durocher,Daniel Durocher,Stephane Angers,Jason Moffat,Jason Moffat +19 more
TL;DR: It is demonstrated that context-dependent fitness genes accurately recapitulate pathway-specific genetic vulnerabilities induced by known oncogenes and reveal cell-type-specific dependencies for specific receptor tyrosine kinases, even in oncogenic KRAS backgrounds.
Journal ArticleDOI
Cancer stem cells: an evolving concept
TL;DR: New insights are obtained into why the CSC concept is not universally applicable, as well as a new basis for understanding the complex evolution, phenotypic heterogeneity and therapeutic challenges of many human cancers.