J
Jane Keating
Researcher at University of Pennsylvania
Publications - 48
Citations - 1105
Jane Keating is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 17, co-authored 34 publications receiving 788 citations. Previous affiliations of Jane Keating include Hospital of the University of Pennsylvania & Hartford Hospital.
Papers
More filters
Journal ArticleDOI
Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery.
John Y K Lee,Jayesh P. Thawani,John T. Pierce,Ryan Zeh,Maria Martinez-Lage,Michelle Chanin,Ollin Venegas,Sarah Nims,Kim O. Learned,Jane Keating,Sunil Singhal +10 more
TL;DR: With the use of Second Window ICG, gadolinium-enhancing tumors can be localized through brain parenchyma intraoperatively and its utility for margin detection is promising but limited by lower specificity.
Journal Article
Optimization of the enhanced permeability and retention effect for near-infrared imaging of solid tumors with indocyanine green.
Jack Jiang,Jane Keating,Elizabeth De Jesus,Ryan Judy,Brian Madajewski,Ollin Venegas,Olugbenga T. Okusanya,Sunil Singhal +7 more
TL;DR: For non-hepatic solid tumors, ICG was optimal when dosed at 5 mg/kg and 24 hours before surgery, and these findings were applicable to lung cancer patients, and tumor was clearly delineated from surrounding normal tissue by NIR imaging.
Journal ArticleDOI
Novel Methods of Intraoperative Localization and Margin Assessment of Pulmonary Nodules.
Jane Keating,Sunil Singhal +1 more
TL;DR: Methods of preoperative lesion marking, including wire placement, dye marking, ultrasound, fluoroscopy, and molecular imaging are examined, and the current state of the art in intraoperative margin assessment techniques are described.
Journal ArticleDOI
Identification of breast cancer margins using intraoperative near-infrared imaging
Jane Keating,Julia Tchou,Olugbenga T. Okusanya,Carla S. Fisher,Rebecca Batiste,Jack Jiang,Gregory T. Kennedy,Shuming Nie,Sunil Singhal +8 more
TL;DR: It is hypothesized that near infrared (NIR) intraoperative molecular imaging using systemic indocyanine green (ICG) would be helpful in discerning tumor margins in intraoperative breast cancer margins.
Journal ArticleDOI
Comparison of Folate Receptor Targeted Optical Contrast Agents for Intraoperative Molecular Imaging
Elizabeth De Jesus,Jane Keating,Sumith A. Kularatne,Jack Jiang,Ryan Judy,Jarrod D. Predina,Shuming Nie,Philip S. Low,Sunil Singhal +8 more
TL;DR: In preclinical testing, OTL38 appears to have superior sensitivity and brightness compared to EC17, which coincides with the accepted belief that near infrared (NIR) dyes tend to have less autofluorescence and scattering issues than visible wavelength fluorochromes.