Ryan Judy

TL;DR: This is the first-in-human demonstration of identifying pulmonary nodules during thoracic surgery with NIR imaging without a priori knowledge of their location or existence.

TL;DR: NIR imaging can identify tumors from normal tissues, provides excellent tissue contrast, and it facilitates the resection of tumors, however, in situations where there is significant peritumoral inflammation, NIR imaging with ICG is not helpful, suggesting that non-targeted NIR dyes that accumulate in hyperpermeable tissues will have significant limitations in the future.

TL;DR: For non-hepatic solid tumors, ICG was optimal when dosed at 5 mg/kg and 24 hours before surgery, and these findings were applicable to lung cancer patients, and tumor was clearly delineated from surrounding normal tissue by NIR imaging.

TL;DR: Intraoperative molecular imaging with a targeted contrast agent can identify lung adenocarcinomas, and this technology is currently useful in patients with subpleural tumors, irrespective of size.

TL;DR: In preclinical testing, OTL38 appears to have superior sensitivity and brightness compared to EC17, which coincides with the accepted belief that near infrared (NIR) dyes tend to have less autofluorescence and scattering issues than visible wavelength fluorochromes.