Ryan Zeh

TL;DR: With the use of Second Window ICG, gadolinium-enhancing tumors can be localized through brain parenchyma intraoperatively and its utility for margin detection is promising but limited by lower specificity.

TL;DR: The Second Window ICG technique allows neurosurgeons to deliver NIR optical contrast agent to human glioblastoma patients, thus providing real-time tumor identification in the operating room and suggests that optimal imaging of the “Second Window of ICG” may be within this plateau period, thereby providing signal uniformity across subjects.

TL;DR: Systemic injection of NIR second-window ICG the day before surgery can be used to visualize meningiomas intraoperatively via preoperative systemic injection of a near-infrared (NIR) fluorescent contrast dye.

TL;DR: Systemic ICG identifies subcentimeter tumor metastases to the lung in murine models and in humans, and this work provides proof of principle in humans.

TL;DR: This work suggests that for adenomas with high FRα expression, it may be possible to identify margins and to predict postoperative MRI findings with perfect concordance, and intraoperative NIR imaging demonstrated perfect classification of the tumor margins with 100% sensitivity and 100% specificity.