J
Julia Tchou
Researcher at University of Pennsylvania
Publications - 147
Citations - 6846
Julia Tchou is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 36, co-authored 130 publications receiving 5643 citations. Previous affiliations of Julia Tchou include Northwestern University & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.
Julia Tchou,H. Kasai,Shinya Shibutani,Myung-Hee Chung,J. Laval,Arthur P. Grollman,Susumu Nishimura +6 more
TL;DR: 8-oxodG DNA is the primary physiological substrate for a constituent glycosylase found in bacteria and mammalian cells, and it is proposed that the existence of a bacterial gene coding for FPG protein is proposed.
Journal ArticleDOI
Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer
Barzin Y. Nabet,Yu Qiu,Jacob E. Shabason,Tony J. Wu,Taewon Yoon,Brian C. Kim,Joseph L. Benci,Angela DeMichele,Julia Tchou,Joseph Marcotrigiano,Andy J. Minn +10 more
TL;DR: Results demonstrate that regulation of RNA unshielding couples stromal activation with deployment of RNA DAMPs that promote aggressive features of cancer.
Journal ArticleDOI
Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.
Julia Tchou,V. Bodepudi,Shinya Shibutani,I Antoshechkin,J Miller,Arthur P. Grollman,Francis Johnson +6 more
TL;DR: Data suggest that the C8 keto group of 8-oxodeoxyguanine and the carbonyl moiety of formamidopyrimidine enable Fpg protein to recognize and bind duplex DNA containing these modified bases.
Journal ArticleDOI
Clinical Diagnosis and Management of Breast Cancer
TL;DR: The diagnosis and management of breast cancer are undergoing a paradigm shift from a one-size-fits-all approach to an era of personalized medicine, including molecular imaging and genomic expression profiles.
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A repair system for 8-oxo-7,8-dihydrodeoxyguanine.
TL;DR: In this article, the MutY glycosylase was shown to be an important part of a repair system that includes the MutM and MutT proteins, which is dedicated to the repair of the oxidatively damaged guanine and mutations it can induce.