Jane M. Sayer

TL;DR: It is demonstrated that ellagic acid is a potent antagonist of the adverse biological effects of the ultimate carcinogenic metabolites of several polycyclic aromatic hydrocarbons and suggested that this naturally occurring plant phenol, normally ingested by humans, may inhibit the carcinogenicity of poly cyclic aromaticHydrocarbons.

TL;DR: Structural differences between complexes N and P suggest that the conserved YMDD loop is involved in translocation, acting as a springboard that helps to propel the primer terminus from the N to the P site after dNMP incorporation.

TL;DR: Myricetin, robinetin and luteolin inhibited the mutagenic activity resulting from the metabolic activation of benzo[a]-pyrene and (+/-)-trans-7,8-dihydroxy-7-8-catechin, genistein, kaempferide and chrysin by rat liver microsomes.

TL;DR: The crystal structure of a BPDE-adenine adduct base-paired with thymine at a template-primer junction and complexed with the lesion-bypass DNA polymerase Dpo4 and an incoming nucleotide is reported, suggesting a mechanism by which mutations are generated during replication of DNA containing B PDE adducts.