H
Hong Ling
Researcher at University of Western Ontario
Publications - 36
Citations - 4015
Hong Ling is an academic researcher from University of Western Ontario. The author has contributed to research in topics: DNA replication & DNA polymerase. The author has an hindex of 22, co-authored 36 publications receiving 3859 citations. Previous affiliations of Hong Ling include National Institutes of Health & Laboratory of Molecular Biology.
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Journal ArticleDOI
Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands
Pavel I. Kitov,Joanna M. Sadowska,George L. Mulvey,Glen D. Armstrong,Hong Ling,Navraj S. Pannu,Randy J. Read,Randy J. Read,David R. Bundle +8 more
TL;DR: The crystal structure of the B5 subunit of Escherichia coli O157:H7 Shiga-like toxin I in complex with an analogue of its carbohydrate receptor is used to design an oligovalent, water-soluble carbohydrate ligand (named STARFISH), with subnanomolar inhibitory activity.
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Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication.
TL;DR: Crystal structures of Dpo4 in ternary complexes with DNA and an incoming nucleotide, either correct or incorrect, have been solved at 1.7 A and 2.1 A resolution, respectively, suggesting a possible mechanism for bypassing thymine dimers.
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Structure of the Shiga-like Toxin I B-Pentamer Complexed with an Analogue of Its Receptor Gb3†,‡
Hong Ling,Amechand Boodhoo,Bart Hazes,Maxwell D. Cummings,Glen D. Armstrong,James L. Brunton,Randy J. Read +6 more
TL;DR: The structural model is consistent with data from site-directed mutagenesis and binding of carbohydrate analogues, and allows the rational design of therapeutic Gb3 analogues that block the attachment of toxin to cells.
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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.
TL;DR: An integrase tetramer formed by crystal lattice contacts bears structural resemblance to a related bacterial transposase, Tn5, and exhibits positively charged channels suitable for DNA binding.
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Replication of a cis-syn thymine dimer at atomic resolution.
TL;DR: Two crystal structures of Dpo4, an archaeal pol η homologue, complexed with CPD-containing DNA are determined, where the 3′ and 5′ thymine of the CPD separately serves as a templating base.