Janet L. Huebner

TL;DR: This study provides the first direct in vivo evidence for macrophage involvement in OA in a substantial proportion of human knees and suggests that drugs targeting macrophages and macrophAGE-associated inflammatory pathways may have the potential to be both symptom and structure modifying.

TL;DR: Wheel-running exercise reduces progression of OA in the medial femur of obese mice and improves glucose tolerance and disrupts the coexpression of proinflammatory cytokines, suggesting that increased aerobic exercise may act independently of weight loss in promoting joint health.

TL;DR: It is suggested that body fat, in and of itself, may not be a risk factor for joint degeneration, because adiposity in the absence of leptin signaling is insufficient to induce systemic inflammation and knee OA in female C57BL/6J mice.

TL;DR: This study demonstrates that articular fractures are associated with a loss of chondrocyte viability and increased levels of systemic biomarkers, and that increased intra-articular fracture severity is associated with increased acute joint pathology in a variety of joint tissues, including synovial inflammation, cortical comminution, and bone morphology.

TL;DR: Interventions teaching overweight and obese OA patients pain coping skills and weight management simultaneously may provide the more comprehensive long‐term benefits.