D
David H. Lovett
Researcher at University of California, San Francisco
Publications - 139
Citations - 9646
David H. Lovett is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Mesangial cell & Matrix metalloproteinase. The author has an hindex of 53, co-authored 139 publications receiving 9164 citations. Previous affiliations of David H. Lovett include University of Wales & United States Department of Veterans Affairs.
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Journal ArticleDOI
Intensity of renal support in critically ill patients with acute kidney injury
Paul M. Palevsky,Jane Hongyuan Zhang,Theresa Z. O'Connor,Glenn M. Chertow,Susan T. Crowley,Devasmita Choudhury,Kevin W. Finkel,John A. Kellum,Emil P. Paganini,Roland M. H. Schein,Mark W. Smith,Kathleen M. Swanson,B. Taylor Thompson,Anitha Vijayan,Suzanne Watnick,Robert A. Star,Peter Peduzzi,E. Young,R. Fissel,W. Fissel,Uptal D. Patel,K. Belanger,A. Raine,N. Ricci,James B. Lohr,P. Arora,D. Cloen,D. Wassel,L. Yohe,J. Amanzadeh,J. Penfield,M. Hussain,R. Katneni,A. Sajgure,A. Swann,G. Dolson,V. Ramanathan,G. Tasby,Robert L. Bacallao,M. Jaradat,Kenneth Edward Graves,Q. Li,M. Krause,M. Shaver,M. Alam,K. Morris,T. Bland,E. Satter,Jeffrey A. Kraut,A. Felsenfeld,B. Levine,G. Nagami,B. Vaghaiwalla,J. Duffney,Joseph O. Moore,C. Cely,E. Jaimes,Daniel H. Kett,Andrew A. Quartin,M. Arcia,A. Barchi-Chung,Vecihi Batuman,A. Alper,A. Dreisbach,E. Simon,C. Kulivan,Nabeel Aslam,M.C. Ramkumar,E. Grum,P. Rogers,Steven D. Weisbord,C. Geffel,Ihab M. Wahba,Darren J. Kelly,J. Walczyk,George Feldman,A. Mogyorosi,G. Viol,M. Halverson,S. Schmid,H. Totten,Francis B. Gabbai,S. Mullaney,R. Smith,J. Dingsdale,S. Woods,Kirsten L. Johansen,David H. Lovett,Ann M. O’Hare,James T. McCarthy,C. Rosado-Rodriguez,A. Galera,G. Rodriguez-Vega,W. Rodriguez,C. Vilchez,B. Young,Dennis L. Andress,A. Lindner,G. Galvin,N. Gourley,Aldo J. Peixoto,M. Perkal,C. Joncas,Sevag Demirjian,J. Yared,R. Brienza,M. Garcia,T. Seifert,L. Sweeney,Hamid Rabb,Mohamed G. Atta,Roy G. Brower,M. Choi,Joseph A. Eustace,Paul J. Scheel,E. Heck,H. Rahman,John L. Niles,H. Bazari,K. Smirnakis,D. Steele,Ravi Thadhani,K. Laliberte,B. Leeman,C. McCarthy,M. Pescatore,Harold M. Szerlip,P. Fall,M. Jagadeesan,Laura L Mulloy,William D Paulson,J. White,N. Sickafoose,K. Cho,M. Gropper,K. Liu,Michael A. Matthay,K. Borovitz,M. Koenigsberg,S. Rodriguez,Gabriel Contreras,S. Cohn,J. Diego,C. Carvalho,D. Carvalho,M. Castro,C. de la Cuesta,I. Espinal,A. Hurtado,P. Oyuela,Mark Unruh,Renee Burr,Michael P. Donahoe,J. Marszalek,M. Shields,R. Venkataraman,J. Aubrecht,H. Sterling,L. Mandich,A. Shaw,J. Foringer,J. Samuels,B. Efron,Michael V. Rocco,E. Deterding,Shahriar Moossavi,C. Bethea,D. McBride,Stuart R. Warren,M. Kollef,K. Sambandam,E. Hammer,M. Hoffman,John B. Stokes,Alfred F. Connors,Harold I. Feldman,Joel W. Greer,G. G. Koch,Thomas E. Stewart,Janet Wittes,P. Overberger,S. Michler,Massimo Antonelli,K. Dellert,L. Durant,R. Franchini,A. Kossack,V. McBride,S. O'Neil,Taposh Roy,J. Russo,Joseph N. Vitale,Mike R. Sather,C. Fye,C. M. Haakenson,D. H. Krueger,J. Thornton,C. Dalzell,R. Horney,Andrew M. Siroka,P. Su,Mary Brophy,D. Humphries,D. Govan,Timothy J. O'Leary,G. D. Huang,John R. Feussner,Paul W. Eggers +207 more
TL;DR: Intensive renal support in critically ill patients with acute kidney injury did not decrease mortality, improve recovery of kidney function, or reduce the rate of nonrenal organ failure as compared with less-intensive therapy.
Journal ArticleDOI
Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation.
Sunfa Cheng,David H. Lovett +1 more
TL;DR: These studies indicate that a discrete matrix metalloproteinase, gelatinase A, is capable of inducing the complex genetic rearrangements that characterize renal tubular epithelial-mesenchymal transformation.
Journal ArticleDOI
Structure and expression of the human gene for the matrix metalloproteinase matrilysin.
Mireille Gaire,Zenaida V. Magbanua,Susan McDonnell,Leslie McNeil,David H. Lovett,Lynn M. Matrisian +5 more
TL;DR: Comparisons and differences observed between the promoters of matrilysin and the other metalloproteinases may provide insights into the molecular mechanisms that regulate the expression of this family of enzymes as a whole and the factors that distinguish the expression patterns of individual family members.
Journal ArticleDOI
Discoidin Domain Receptor 2 Regulates Fibroblast Proliferation and Migration through the Extracellular Matrix in Association with Transcriptional Activation of Matrix Metalloproteinase-2
Elvira Olaso,Juan-Pablo Labrador,Li-Hsien Wang,Kazuo Ikeda,Francis J. Eng,Rüdiger Klein,David H. Lovett,Hsin Chieh Lin,Scott L. Friedman +8 more
TL;DR: Stable reconstitution of either wild-type DDR2 or constitutively active chimeric DDR2 in DDR2−/−cells by retroviral infection restored cell proliferation, migration through a reconstituted basement membrane (Matrigel), and MMP-2 levels to those of DDR2+/− fibroblasts.
Journal ArticleDOI
Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury
TL;DR: It is demonstrated that transgenic renal proximal tubular epithelial expression of a specific enzyme, MMP‐2, is sufficient to generate the entire spectrum of pathological and functional changes characteristic of human CKD.