J
Janette E. Bradley
Researcher at University of Nottingham
Publications - 107
Citations - 3874
Janette E. Bradley is an academic researcher from University of Nottingham. The author has contributed to research in topics: Population & Onchocerca volvulus. The author has an hindex of 33, co-authored 103 publications receiving 3616 citations. Previous affiliations of Janette E. Bradley include University of Manchester & University of Salford.
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Journal ArticleDOI
Th2 Cytokines Are Associated with Reduced Worm Burdens in a Human Intestinal Helminth Infection
Joseph D. Turner,Helen Faulkner,J. Kamgno,Frances Cormont,Jacques Van Snick,Kathryn J. Else,Richard K. Grencis,Jerzy M. Behnke,Michel Boussinesq,Janette E. Bradley +9 more
TL;DR: A role for Th2-mediated responses in the age-dependent reduction of intestinal helminth infections in humans is promoted after it was found the intensity of A. lumbricoides infection was significantly reduced after age 11 years.
Journal ArticleDOI
Review series on helminths, immune modulation and the hygiene hypothesis: Immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?
TL;DR: The very ancient and pervasive relationship between vertebrates and helminths supports a view that immunological control networks have been selected to function within the context of a modified Th2 environment, and the absence of immunoregulatory stimuli from helminths may uncover maladaptations that were not previously exposed to selection.
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Modulation of Human T Cell Responses and Macrophage Functions by Onchocystatin, a Secreted Protein of the Filarial Nematode Onchocerca volvulus
Annett A. Schönemeyer,Richard Lucius,Bettina Sonnenburg,Norbert Brattig,Robert Sabat,Klaus Schilling,Janette E. Bradley,Susanne Hartmann +7 more
TL;DR: Recombinant onchocystatin has the potential to contribute to a state of cellular hyporesponsiveness and is a possible pathogenicity factor essential for the persistence of O. volvulus within its human host.
Journal ArticleDOI
Onchocerciasis modulates the immune response to mycobacterial antigens.
Graham R. Stewart,Michel Boussinesq,Tim Coulson,Lynne Elson,Thomas B. Nutman,Janette E. Bradley,Janette E. Bradley +6 more
TL;DR: This parasite‐induced immunomodulation of the response to mycobacteria correlates with a previous report of doubled incidence of lepromatous leprosy in onchocerciasis hyperendemic regions, and demonstrates that helminth infection in humans can modulate the immune response to a concurrent infection or immunological challenge.
Journal ArticleDOI
Immunity to onchocerciasis : putative immune persons produce a Th1-like response to Onchocerca volvulus
Lynne Elson,H. Manuel Calvopiña,Y Wilson Paredes,N Edmundo Araujo,Janette E. Bradley,Ronald H. Guderian,Thomas B. Nutman +6 more
TL;DR: Cytokine analysis of PBMC culture supernatants revealed that immunity to Ov may in part be mediated by an antigen-specific Th1-type response.