R
Richard K. Grencis
Researcher at Wellcome Trust Centre for Cell-Matrix Research
Publications - 183
Citations - 13241
Richard K. Grencis is an academic researcher from Wellcome Trust Centre for Cell-Matrix Research. The author has contributed to research in topics: Trichuris muris & Immune system. The author has an hindex of 63, co-authored 177 publications receiving 11906 citations. Previous affiliations of Richard K. Grencis include University of California, Irvine & University of Manchester.
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Journal ArticleDOI
Cytokine-mediated regulation of chronic intestinal helminth infection.
TL;DR: Depletion of interferon (IFN)- gamma in normally susceptible mice resulted in expulsion of the parasite, representing the first evidence for a role for IFN-gamma in the establishment of chronic helminth infection.
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Impaired Development of Th2 Cells in IL-13-Deficient Mice
Grahame James Mckenzie,Claire Emson,Sarah Bell,Shannon Anderson,Padraic G. Fallon,Gerard Zurawski,Richard Murray,Richard K. Grencis,Andrew N. J. McKenzie +8 more
TL;DR: It is reported that Th2 cell cultures generated using T cells or splenocytes from IL-13-deficient mice produce significantly reduced levels of IL-4, IL-5, and IL-10 compared with wild-type, suggesting IL- 13 is an important regulator of Th2 commitment and may therefore play a central role in atopy and infectious diseases.
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Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion.
Laura J. Cliffe,Neil E. Humphreys,Neil E. Humphreys,Thomas E. Lane,Thomas E. Lane,Chris S. Potten,Chris S. Potten,Cath Booth,Cath Booth,Richard K. Grencis,Richard K. Grencis +10 more
TL;DR: It is shown that an increase in the rate of epithelial cell turnover in the large intestine acts like an “epithelial escalator” to expel Trichuris and that the rates of epithel cell movement is under immune control by the cytokine interleukin-13 and the chemokine CXCL10.
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IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes
TL;DR: The ability of IL-33 to induce Th2 responses has functional relevance in the context of intestinal helminth infection, particularly during the initiation of the response.
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A distinct role for interleukin-13 in Th2-cell-mediated immune responses
TL;DR: It is demonstrated that, unlike wild-type and IL-4-/- mice, the IL-13-/- animals failed to clear N. brasiliensis infections efficiently, despite developing a robust Th2-like cytokine response to infection, and this observation may linkIL-13 with the production of intestinal mucus which is believed to facilitate worm expulsion.