Janice S. Lee

TL;DR: A review of emerging issues and research needs to address the multi-faceted challenges related to arsenic and environmental health and suggests integration of omics data with mechanistic and epidemiological data is a key step toward the goal of linking biomarkers of exposure and susceptibility to disease mechanisms and outcomes.

TL;DR: It is indicated that PFOA alters most genes in wild-type mouse liver through PPARalpha, but that a subset of genes are regulated by CAR and possibly PPAR gamma in the PPAR alpha-null mouse.

TL;DR: The study factors that emerged as key sources of variability included gender, organ section, strain, and fasting state and were identified as key descriptors that should be included in the minimal information about a toxicogenomics study needed for interpretation of results by an independent source.

TL;DR: Surprisingly, around half of the genes altered by aging in wild-type mice exhibited similar expression changes in adult long-lived mice compared to wild- type controls, including those associated with intermediary metabolism and feminization of the male-dependent gene expression pattern.

TL;DR: Examination of transcriptional responses across lifespan after challenge with a xenobiotic compound showed decreased ability to detoxify and transport chemicals out of the body with age could result in increased susceptibility to some classes of chemicals in the aging population.