J
Jiusheng Deng
Researcher at Harvard University
Publications - 4
Citations - 1695
Jiusheng Deng is an academic researcher from Harvard University. The author has contributed to research in topics: Scavenger receptor & Signal transduction. The author has an hindex of 2, co-authored 2 publications receiving 1514 citations.
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Journal ArticleDOI
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Cameron R. Stewart,Lynda M. Stuart,Kim Wilkinson,Janine M. van Gils,Jiusheng Deng,Annett Halle,Annett Halle,Katey J. Rayner,Laurent Boyer,Ruiqin Zhong,William A. Frazier,Adam Lacy-Hulbert,Joseph El Khoury,Douglas T. Golenbock,Kathryn J. Moore,Kathryn J. Moore +15 more
TL;DR: It is shown that oxidized LDL and amyloid-β trigger inflammatory signaling through a heterodimer of Toll-like receptors 4 and 6 that is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands.
Journal ArticleDOI
Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
Lynda M. Stuart,Jiusheng Deng,Jessica M. Silver,Kazue Takahashi,Anita A. Tseng,Elizabeth J. Hennessy,R. Alan B. Ezekowitz,Kathryn J. Moore +7 more
TL;DR: In this article, the Drosophila melanogaster scavenger receptor Croquemort was identified as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors for bacteria.
Journal Article
Silence of FIZZ1 by Short Hairpin RNA Inhibits Atherosclerosis.
TL;DR: In this paper , the effects of FIZZ1 on the development of atherosclerosis were studied in vitro and in vivo with ApoE-/- mice, where the authors used an adenoviral vector to encode FizZ1 short hairpin RNA (Ad-shFIZZ1).
Journal ArticleDOI
Molecular Determinants of Human Red Blood Cell Survival in Murine Circulation
Jiusheng Deng,Moira M. Lancelot,Ryan P. Jajosky,Marianne E.M. Yee,Natia Saakadze,Sean R Stowell,John D. Roback +6 more
TL;DR: In this paper , the authors show that CD47 and CD59 expression on human red blood cells increases their survival after transfusion, and suggest that pre-transfusion profiling of CD 47 and CD 59 molecules could help predict the efficiency of human RBC transfusion.