Janine Müller

TL;DR: A novel, readily accessible source of multipotent human NCSCs for potential cell-replacement therapy is described and a separation strategy based on magnetic cell sorting of p75(NTR) positive ITSCs that formed larger neurospheres and proliferated faster than p75-NTR negative ITSCs is developed.

TL;DR: A novel mode of action of 1,8-cineol through inhibition of nuclear NF-κB p65 translocation via IκBα resulting in decreased levels of proinflammatory NF-kkB target genes is suggested and may therefore broaden the field of clinical application of this natural drug for treating inflammatory diseases.

TL;DR: A novel, human blood plasma based semi-solid medium for cultivation of human neural crest-derived inferior turbinate stem cells (ITSCs) within a blood plasma matrix, where they revealed higher proliferation rates compared to a standard serum-free approach.

TL;DR: It is demonstrated, for the first time, that adult human ITSCs are capable of functionally recovering a PD rat model.

TL;DR: It is demonstrated for the first time that 1,8-cineole potentiates poly(I:C)-induced activity of the antiviral transcription factor interferon regulatory factor 3 (IRF3), while simultaneously reducing proinflammatory nuclear factor (NF)-κB activity in human cell lines, inferior turbinate stem cells and in ex vivo cultivated human nasal mucosa.