Jared E. Knickelbein

TL;DR: It is found that CD8+ T cell lytic granules are also required for the maintenance of neuronal latency both in vivo and in ex vivo ganglia cultures and that their directed release to the junction with neurons in latently infected ganglia did not induce neuronal apoptosis.

TL;DR: The present aim is to review the current evidence-based treatment options including and beyond the use of corticosteroids and antivirals and to cultivate insights into developing therapeutic vaccination strategies to inhibit HSV stromal keratitis recurrences.

TL;DR: Transgenic mice that express enhanced green fluorescent protein from the CD 11c promoter are utilized in conjunction with immunohistochemical staining to demonstrate an interesting stratification of APCs within non-inflamed murine corneas, suggestive of a progression from an APC function at the exposed corneal surface to an innate immune barrier function deeper in the stroma.

TL;DR: The concept of parainflammation has been suggested to describe inflammatory responses to tissue stress that are intermediate between basal and robust inflammatory states and function in a reparative manner in AMD, which is not accompanied by an intense inflammatory reaction.

TL;DR: The results suggest that the CD8+ TSCM subset is a novel biomarker and a potential therapeutic target for AA and Evaluation of PD-1, CD160, and CD244 expression revealed that TSCMs were less exhausted compared with other types of memory T cells.