P
Pawel Muranski
Researcher at Columbia University Medical Center
Publications - 86
Citations - 10441
Pawel Muranski is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 33, co-authored 80 publications receiving 8991 citations. Previous affiliations of Pawel Muranski include Columbia University & National Institutes of Health.
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Journal ArticleDOI
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
Luca Gattinoni,Xiao-Song Zhong,Douglas C. Palmer,Yun Ji,Christian S. Hinrichs,Zhiya Yu,Claudia Wrzesinski,Andrea Boni,Lydie Cassard,Lindsay M. Garvin,Chrystal M. Paulos,Pawel Muranski,Nicholas P. Restifo +12 more
TL;DR: Findings reveal a key role for Wnt signaling in the maintenance of 'stemness' in mature memory CD8+ T cells and have major implications for the design of new vaccination strategies and adoptive immunotherapies.
Journal ArticleDOI
Tumor-specific Th17-polarized cells eradicate large established melanoma
Pawel Muranski,Andrea Boni,Paul A. Antony,Lydie Cassard,Kari R. Irvine,Andrew Kaiser,Chrystal M. Paulos,Douglas C. Palmer,Christopher E. Touloukian,Krzysztof Ptak,Luca Gattinoni,Claudia Wrzesinski,Christian S. Hinrichs,Keith W. Kerstann,Lionel Feigenbaum,Chi-Chao Chan,Nicholas P. Restifo +16 more
TL;DR: Data indicate that the appropriate in vitro polarization of effector CD4+ T cells is decisive for successful tumor eradication, and this principle should be considered in designing clinical trials involving adoptive transfer-based immunotherapy of human malignancies.
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Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
Sergio A. Quezada,Tyler R. Simpson,Karl S. Peggs,Taha Merghoub,Jelena Vider,Xiaozhou Fan,Ronald G. Blasberg,Hideo Yagita,Pawel Muranski,Paul A. Antony,Nicholas P. Restifo,James P. Allison +11 more
TL;DR: It is found that transfer of small numbers of naive tumor-reactive CD4+ T cells into lymphopenic recipients induces substantial T cell expansion, differentiation, and regression of large established tumors without the need for in vitro manipulation.
Journal ArticleDOI
T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity
Natalia Martin-Orozco,Pawel Muranski,Yeonseok Chung,Xuexian O. Yang,Tomohide Yamazaki,Sijie Lu,Patrick Hwu,Nicholas P. Restifo,Willem W. Overwijk,Chen Dong +9 more
TL;DR: Th17 cells elicited a protective inflammation that promotes the activation of tumor-specific CD8(+) T cells, which were necessary for the antitumor effect in mice that were more susceptible to developing lung melanoma.
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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Madhusudhanan Sukumar,Jie Liu,Yun Ji,Murugan Subramanian,Joseph G. Crompton,Zhiya Yu,Rahul Roychoudhuri,Douglas C. Palmer,Pawel Muranski,Edward D. Karoly,Robert P. Mohney,Christopher A. Klebanoff,Ashish Lal,Toren Finkel,Nicholas P. Restifo,Luca Gattinoni +15 more
TL;DR: It is indicated that augmenting glycolytic flux drives CD8+ T cells toward a terminally differentiated state, while its inhibition preserves the formation of long-lived memory CD8+, and the efficacy of T cell-based therapies against chronic infectious diseases and cancer.