D
Danielle M. Townsley
Researcher at National Institutes of Health
Publications - 77
Citations - 3085
Danielle M. Townsley is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Aplastic anemia & Eltrombopag. The author has an hindex of 22, co-authored 74 publications receiving 2365 citations. Previous affiliations of Danielle M. Townsley include MedImmune.
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Journal ArticleDOI
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
Tetsuichi Yoshizato,Bogdan Dumitriu,Kohei Hosokawa,Hideki Makishima,Kenichi Yoshida,Danielle M. Townsley,Aiko Sato-Otsubo,Yusuke Sato,Delong Liu,Hiromichi Suzuki,Colin O. Wu,Yuichi Shiraishi,Michael J. Clemente,Keisuke Kataoka,Yusuke Shiozawa,Yusuke Okuno,Kenichi Chiba,Hiroko Tanaka,Yasunobu Nagata,Takamasa Katagiri,Ayana Kon,Masashi Sanada,Phillip Scheinberg,Satoru Miyano,Jaroslaw P. Maciejewski,Shinji Nakao,Neal S. Young,Seishi Ogawa +27 more
TL;DR: A highly biased set of mutations is evidence of Darwinian selection in the failed bone marrow environment and might not necessarily have predicted the response to therapy and long-term survival among individual patients.
Journal ArticleDOI
Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.
Danielle M. Townsley,Phillip Scheinberg,Thomas Winkler,Ronan Desmond,Bogdan Dumitriu,Olga Rios,Barbara Weinstein,Janet Valdez,Jennifer Lotter,Xingmin Feng,Marie J. Desierto,Harshraj Leuva,Margaret Bevans,Colin O. Wu,Andre Larochelle,Katherine R. Calvo,Cynthia E. Dunbar,Neal S. Young +17 more
TL;DR: The addition of eltrombopag to immunosuppressive therapy was associated with markedly higher rates of hematologic response among patients with severe aplastic anemia than in a historical cohort.
Journal ArticleDOI
Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug
Ronan Desmond,Danielle M. Townsley,Bogdan Dumitriu,Matthew J. Olnes,Phillip Scheinberg,Margaret Bevans,Ankur R. Parikh,Kinneret Broder,Katherine R. Calvo,Colin O. Wu,Neal S. Young,Cynthia E. Dunbar +11 more
TL;DR: Eltrombopag is efficacious in a subset of patients with aplastic anemia refractory to immunosuppressive therapy, with frequent multilineage responses and maintenance of normalized hematopoiesis off treatment.
Journal ArticleDOI
Danazol Treatment for Telomere Diseases.
Danielle M. Townsley,Bogdan Dumitriu,Delong Liu,Angelique Biancotto,Barbara Weinstein,Christina Chen,Nathan Hardy,Andrew D Mihalek,Shilpa Lingala,Yun Ju Kim,Jianhua Yao,Elizabeth C. Jones,Bernadette R. Gochuico,Theo Heller,Colin O. Wu,Rodrigo T. Calado,Phillip Scheinberg,Neal S. Young +17 more
TL;DR: Treatment with danazol led to telomere elongation in patients with Telomere diseases, and this study is the first to show this effect in a phase 1-2 prospective study involving patients with telomeres diseases.
Journal ArticleDOI
Bone marrow failure and the telomeropathies
TL;DR: Telomere biology is complexly related to oncogenesis: telomere attrition is protective by enforcing senescence or apoptosis in cells with a long mitotic history, buttelomere loss also can destabilize the genome by chromosome rearrangement and aneuploidy.