B
Bogdan Dumitriu
Researcher at National Institutes of Health
Publications - 49
Citations - 3908
Bogdan Dumitriu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Aplastic anemia & Telomerase. The author has an hindex of 19, co-authored 49 publications receiving 3241 citations. Previous affiliations of Bogdan Dumitriu include Cleveland Clinic Lerner Research Institute & University of São Paulo.
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Journal ArticleDOI
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
Hye Sun Kuehn,Weiming Ouyang,Bernice Lo,Elissa K. Deenick,Elissa K. Deenick,Julie E. Niemela,Danielle T. Avery,Jean Nicolas Schickel,Dat Q. Tran,Jennifer Stoddard,Yu Zhang,David M. Frucht,Bogdan Dumitriu,Phillip Scheinberg,Les R. Folio,Cathleen Frein,Susan Price,Christopher Koh,Theo Heller,Christine M. Seroogy,Anna Huttenlocher,V. Koneti Rao,Helen C. Su,David E. Kleiner,Luigi D. Notarangelo,Yajesh Rampertaap,Kenneth N. Olivier,Joshua J McElwee,Jason D. Hughes,Stefania Pittaluga,Joao Bosco Oliveira,Eric Meffre,Thomas A. Fleisher,Steven M. Holland,Michael J. Lenardo,Stuart G. Tangye,Stuart G. Tangye,Gulbu Uzel +37 more
TL;DR: The findings support the idea that CTLA4 tells the immune system when enough is enough, and Inherited human CTLA 4 haploinsufficiency demonstrates a critical quantitative role for CTLA-4 in governing T and B lymphocyte homeostasis.
Journal ArticleDOI
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
Tetsuichi Yoshizato,Bogdan Dumitriu,Kohei Hosokawa,Hideki Makishima,Kenichi Yoshida,Danielle M. Townsley,Aiko Sato-Otsubo,Yusuke Sato,Delong Liu,Hiromichi Suzuki,Colin O. Wu,Yuichi Shiraishi,Michael J. Clemente,Keisuke Kataoka,Yusuke Shiozawa,Yusuke Okuno,Kenichi Chiba,Hiroko Tanaka,Yasunobu Nagata,Takamasa Katagiri,Ayana Kon,Masashi Sanada,Phillip Scheinberg,Satoru Miyano,Jaroslaw P. Maciejewski,Shinji Nakao,Neal S. Young,Seishi Ogawa +27 more
TL;DR: A highly biased set of mutations is evidence of Darwinian selection in the failed bone marrow environment and might not necessarily have predicted the response to therapy and long-term survival among individual patients.
Journal ArticleDOI
Control of Cell Fate and Differentiation by Sry-related High-mobility-group Box (Sox) Transcription Factors
TL;DR: The Sox family controls cell fate and differentiation in a multitude of processes, such as male differentiation, stemness, neurogenesis, and skeletogenesis, and they review their specific molecular properties and in vivo roles, stress recent advances in the field, and suggest directions for future investigations.
Journal ArticleDOI
Eltrombopag and Improved Hematopoiesis in Refractory Aplastic Anemia
Matthew J. Olnes,Phillip Scheinberg,Katherine R. Calvo,Ronan Desmond,Yong Tang,Bogdan Dumitriu,Ankur R. Parikh,Susan Soto,Angelique Biancotto,Xingmin Feng,Jay N. Lozier,Colin O. Wu,Neal S. Young,Cynthia E. Dunbar +13 more
TL;DR: Treatment with eltrombopag was associated with multilineage clinical responses in some patients with refractory severe aplastic anemia and may improve blood counts.
Journal ArticleDOI
Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.
Danielle M. Townsley,Phillip Scheinberg,Thomas Winkler,Ronan Desmond,Bogdan Dumitriu,Olga Rios,Barbara Weinstein,Janet Valdez,Jennifer Lotter,Xingmin Feng,Marie J. Desierto,Harshraj Leuva,Margaret Bevans,Colin O. Wu,Andre Larochelle,Katherine R. Calvo,Cynthia E. Dunbar,Neal S. Young +17 more
TL;DR: The addition of eltrombopag to immunosuppressive therapy was associated with markedly higher rates of hematologic response among patients with severe aplastic anemia than in a historical cohort.