J
Jarosław Sączewski
Researcher at Gdańsk Medical University
Publications - 42
Citations - 414
Jarosław Sączewski is an academic researcher from Gdańsk Medical University. The author has contributed to research in topics: Lipophilicity & Electrophilic amination. The author has an hindex of 10, co-authored 39 publications receiving 298 citations. Previous affiliations of Jarosław Sączewski include Georgia State University.
Papers
More filters
Journal ArticleDOI
Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules
TL;DR: This review provides a comprehensive resource, summarizing a broad range of important quinolone applications with great utility as a resource concerning both chemical modifications and also novel hybrid bifunctional therapeutic agents.
Journal ArticleDOI
Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents.
Joanna Fedorowicz,Jarosław Sączewski,Agnieszka Konopacka,Krzysztof Waleron,Dawid Lejnowski,Krzesimir Ciura,Tihomir Tomašič,Žiga Skok,Kirsi Savijoki,Małgorzata Morawska,Shella Gilbert-Girard,Adyary Fallarero +11 more
TL;DR: A series of novel fluoroquinolone-Safirinium dye hybrids was synthesized by means of tandem Mannich-electrophilic amination reactions from profluorophoric isoxazolones and antibiotics bearing a secondary amino group at position 7 of the quinoline ring to demonstrate low propensity for resistance development.
Journal ArticleDOI
Synthesis, X-ray structure analysis and computational studies of novel bis(thiocarbamoyl) disulfides with non-covalent S···N and S···S interactions
Jarosław Sączewski,Antonio Frontera,Maria Gdaniec,Zdzisław Brzozowski,Franciszek Sączewski,Piotr Tabin,David Quiñonero,Pere M. Deyà +7 more
TL;DR: In this paper, the synthesis of bis(thiocarbamoyl) disulfides that present interesting intramolecular S−N and S−S interactions was described, and the non-covalent interactions have been studied analyzing the crystal structure and by means of high level density functional theory (DFT) calculations (RI-PB86/TZVP) using both AIM and natural bond orbital (NBO) analyses.
Journal ArticleDOI
Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches.
Krzesimir Ciura,Joanna Fedorowicz,Filip Andrić,Katarzyna E. Greber,Alina Gurgielewicz,Wiesław Sawicki,Jarosław Sączewski +6 more
TL;DR: In this paper, a series of hybrid quaternary ammonium-fluoroquinolone-Safirinium derivatives have been synthesized as new dual-acting hydrophilic antibacterial agents.
Journal ArticleDOI
Hybrid Molecules Composed of 2,4-Diamino-1,3,5-triazines and 2-Imino-Coumarins and Coumarins. Synthesis and Cytotoxic Properties
TL;DR: In vitro anticancer activity of the newly prepared 2-imino-2H-chromen-3-yl-1,3,5-triazine compounds was evaluated against five human cancer cell lines: DAN-G, A-427, LCLC-103H, SISO and RT-4.