Jasimuddin Ahamed

TL;DR: A dichotomous role of megakaryocytes (MKs) in both maintaining HSC quiescence during homeostasis and promoting HSC regeneration after chemotherapeutic stress is reported, demonstrating that MKs serve as HSC-derived niche cells to dynamically regulate HSC function.

TL;DR: It is shown that the tissue factor (TF)-VIIa protease complex, independent of triggering coagulation, can promote tumor and developmental angiogenesis through protease-activated receptor-2 (PAR-2) signaling, and targeting the TF-VIIa signaling pathway may enhance the efficacy of angiostatic treatments for cancer and neovascular eye diseases.

TL;DR: An upstream regulatory mechanism that controls TF function is delineated, linking the regulation of TF thrombogenicity to oxidative stress in the vasculature and a unique monoclonal antibody recognizes only the noncoagulant, cryptic conformation of TF.

TL;DR: The results show that tumor cell TF-PAR2 signaling is crucial for tumor growth and suggest that anti-TF strategies can be applied in cancer therapy with minor impairment of TF-dependent hemostatic pathways.

TL;DR: The molecular mechanisms of tissue factor pathways in angiogenesis and tumorigenesis are reviewed with emphasis on the intriguing role for tissue factor cytoplasmic domain signaling.