Heather Marshall

TL;DR: A dichotomous role of megakaryocytes (MKs) in both maintaining HSC quiescence during homeostasis and promoting HSC regeneration after chemotherapeutic stress is reported, demonstrating that MKs serve as HSC-derived niche cells to dynamically regulate HSC function.

TL;DR: Hox-2.9 was expressed in the ectopic r4 as strongly as in the normal r4, whereas reciprocal grafts of future r2 to r4 position did not express Hox- 2.9, suggesting that Hox genes confer positional value.

TL;DR: It is suggested that CNC cells control craniofacial development by regulating positional interactions with mesoderm-derived muscle progenitors that together shape the cranial musculoskeletal architecture in vertebrate embryos.

TL;DR: It is found that the patterns of Hoxa3 and Hoxb3 expression in r5 and r6 in later stages during mouse and chick hindbrain development were differentially regulated, adding further strength to the emerging importance of positive auto- and cross-regulatory interactions between Hox genes as a general mechanism for maintaining their correct spatial patterns in the vertebrate nervous system.

TL;DR: RHSCs were preferentially maintained in the endosteal region that enriches N- cadherin+ (N-cad+) bone-lining cells in homeostasis and post-chemotherapy, and ablation of N-Cad+ niche cells or deletion of SCF from N-cads niche cells impaired rHSC maintenance during homeostasi and regeneration.